Differential longitudinal changes of hippocampal subfields in patients with anorexia nervosa.

Our study provides evidence of differential volumetric differences in hippocampal subfields between individuals with AN and HC and almost complete normalization after weight rehabilitation. These alterations are spatially inhomogeneous and more pronounced compared to other major mental disorders (e.g., major depressive disorder, schizophrenia). We provide novel insights linking hypoleptinemia to hippocampal subfield alterations hinting towards clinical relevance of leptin normalization in AN recovery. This article is protected by copyright. All rights reserved.