Mutations in NLRP2 and NLRP5 cause female infertility characterised by early embryonic arrest.

Jian MuWenjing WangBiaobang ChenLing WuBin LiXiaoyan MaoZhihua ZhangJing FuYanping KuangXiaoxi SunQiaoli LiLi JinLin HeQing SangLei Wang

Published in: Journal of medical genetics (2019)

NLRP2 and NLRP5 are novel mutant genes responsible for human early embryonic arrest. This finding provides additional potential diagnostic markers for patients with recurrent failure of ART and helps us to better understand the genetic basis of female infertility characterised by early embryonic arrest.

Keyphrases

cell cycle
nlrp inflammasome
endothelial cells
type diabetes
gene expression
cell proliferation
metabolic syndrome
transcription factor
dna methylation
human health
pluripotent stem cells