Functional roles of microRNAs in vasculogenic mimicry and resistance to therapy in human cancers: an update.
Alejandra Paola García-HernándezGricelda Sánchez-SánchezAngeles Carlos-ReyesCesar López-CamarilloPublished in: Expert review of clinical immunology (2024)
The miRNAs are regulators of protein-encoding genes involved in VM; however, their specific expression signatures with clinical value in large cohorts of patients have not been established yet. We considered that genomic profiling of miRNAs could be useful to define some hallmarks of tumors such as stemness, drug resistance, and VM in cancer patients. However, additional studies are needed to establish the relevant role of miRNAs as effective therapeutic targets in tumors that have developed VM.
Keyphrases
- end stage renal disease
- endothelial cells
- newly diagnosed
- ejection fraction
- stem cells
- poor prognosis
- chronic kidney disease
- binding protein
- prognostic factors
- transcription factor
- single cell
- gene expression
- protein protein
- patient reported outcomes
- signaling pathway
- case control
- patient reported
- cell therapy
- smoking cessation