A robust CRISPR-Cas12a biosensor coated with metal-organic framework.

Lingjun ShaYiwei HanMinghui WangShuai WuJie YangGenxi Li

Published in: Journal of materials chemistry. B (2022)

Metal-organic frameworks (MOFs) are proposed to protect a CRISPR-associated enzyme/RNA complex from harsh environments, while the complex can be quickly released from MOFs with high efficiency. Therefore, the application of CRISPR-powered biosensing can be more feasible.

Keyphrases

metal organic framework
crispr cas
genome editing
high efficiency
genome wide
label free
gold nanoparticles
sensitive detection
nucleic acid