Isopanepoxydone inhibits oxidative damage in murine alveolar macrophages via NRF2 and NLRP3 inflammasome.

Yuan Yee Lee Hossain Mohammad Arif UllahLee Su HaSung Dae Kim Bong-Sik Yun Man Hee Rhee

Published in: Immunopharmacology and immunotoxicology (2022)

Pathways of action of ISO in MH-S cells that prevent oxidative damage and suppress the expression of proteins in the inflammasome pathway were investigated. ISO may be developed as a treatment for respiratory inflammation.

Keyphrases

nlrp inflammasome
oxidative stress
induced apoptosis
poor prognosis
cell cycle arrest
binding protein
atomic force microscopy
high resolution