Beneficial Effects of Cannabis on Blood-Brain Barrier Function in Human Immunodeficiency Virus.

Ronald J EllisScott PetersonMariana ChernerErin MorganRachel SchrierBin TangMartin HoeniglScott LetendreJenny Iudicello

Published in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2021)

Cannabis may have a beneficial impact on HIV-associated BBB injury. Since BBB disruption may permit increased entry of toxins such as microbial antigens and inflammatory mediators, with consequent CNS injury, these results support a potential therapeutic role of cannabis among PWH and may have important treatment implications for ART effectiveness and toxicity.

Keyphrases

blood brain barrier
human immunodeficiency virus
antiretroviral therapy
hiv infected
hepatitis c virus
hiv positive
hiv aids
cerebral ischemia
oxidative stress
randomized controlled trial
systematic review
microbial community
brain injury
combination therapy
replacement therapy