Spondyloarthritis, acute anterior uveitis, and Crohn's disease have both shared and distinct gut microbiota.
Morgan EssexValeria Rios RodriguezJudith RademacherFabian ProftUlrike LöberLajos MarkóUwe PleyerTill StrowigJérémy MarchandJennifer A KirwanBritta SiegmundSofia K ForslundDenis PoddubnyyPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2023)
Our work supports the existence of a common gut dysbiosis in SpA and related inflammatory pathologies. We reveal shared and disease-specific microbial associations and suggest potential mediators of disease activity. Validation studies are needed to clarify the role of Fusicatenibacter in gut-joint inflammation, and metagenomic resolution is needed to understand the relationship between Faecalibacterium commensals and HLA-B27.
Keyphrases
- disease activity
- ankylosing spondylitis
- rheumatoid arthritis
- systemic lupus erythematosus
- juvenile idiopathic arthritis
- rheumatoid arthritis patients
- oxidative stress
- microbial community
- respiratory failure
- drug induced
- intensive care unit
- genome wide
- single molecule
- dna methylation
- wastewater treatment
- human health
- case control