A Histone Methylation-MAPK Signaling Axis Drives Durable Epithelial-Mesenchymal Transition in Hypoxic Pancreatic Cancer.
Brooke A BrownPaul J MyersSara J AdairJason R PitarresiShiv K Sah-TeliLogan A CampbellWilliam S HartMichelle C BarbeauKelsey LeongNicholas SeylerWilliam J KaneKyoung Eun LeeEdward B StelowMarieke K JonesM Celeste SimonPeppi KarppinenTodd W BauerBen Z StangerMatthew J LazzaraPublished in: Cancer research (2024)
Integrated regulation of histone methylation and MAPK signaling by the low-oxygen environment of pancreatic cancer drives long-lasting EMT that promotes chemoresistance and shortens patient survival and that can be pharmacologically inhibited. See related commentary by Wirth and Schneider, p. 1739.