Expression of PD-L1, PD-L2, and IDO1 on tumor cells and density of CD8-positive tumor-infiltrating lymphocytes in early-stage lung adenocarcinoma according to histological subtype.
Kazuki TakadaGouji ToyokawaFumihiko KinoshitaTomoko JogoKenichi KohashiSho WakasuYuki OnoKensuke TanakaTaro ObaAtsushi OsoegawaTetsuzo TagawaKoichi AzumaIsamu OkamotoMototsugu ShimokawaYoshinao OdaMasaki MoriPublished in: Journal of cancer research and clinical oncology (2020)
No cases in Groups A and B expressed PD-L1. The expression of immune-related factors, especially PD-L1 and IDO1, was significantly associated with Group C. This is the first report of the detailed examination of PD-L1, PD-L2, IDO1, and CD8 expression in lung adenocarcinoma subtypes with lepidic predominant components. Our results could help identify patients who would benefit from perioperative immunotherapy.