Interactions of obesity, body shape, diabetes and sex steroids with respect to prostate cancer risk in the UK Biobank cohort.

Sofia Christakoudi Konstantinos K TsilidisEvangelos EvangelouElio Riboli

Published in: Cancer medicine (2024)

Obesity and diabetes showed synergistic inverse associations with prostate cancer risk, likely involving testosterone reduction for diabetes and oestrogen generation for obesity, which were attenuated for high-ABSI. HI and SHBG showed synergistic inverse associations with prostate cancer risk.

Keyphrases

type diabetes
prostate cancer
insulin resistance
weight loss
glycemic control
metabolic syndrome
cardiovascular disease
high fat diet induced
weight gain
radical prostatectomy
cancer therapy
benign prostatic hyperplasia
adipose tissue
cross sectional
skeletal muscle
drug delivery
replacement therapy