Southern Chinese populations harbour non-nucleatum Fusobacteria possessing homologues of the colorectal cancer-associated FadA virulence factor.
Yun Kit YeohZigui ChenMartin C S WongMamie HuiJun YuWilliam K K WuJoseph J Y SungFrancis Ka Leung ChanPaul K S ChanPublished in: Gut (2020)
The proportion of fusobacteria in guts of southern Chinese populations are higher compared with several western and rural populations in line with the notion of environment/biogeography driving human gut microbiome composition. Several non-nucleatum taxa possess FadA homologues and were enriched in CRC cohorts; whether this imposes a risk in developing CRC and other gut diseases deserves further investigation.