Insulin B peptide-MHC class II-specific chimeric antigen receptor-Tregs prevent autoimmune diabetes.

Justin A SpanierVivian FungChristine M WardellMohannad H AlkhatibYixin ChenLinnea A SwansonAlexander J DwyerMatthew E WenoNubia SilvaJason S MitchellPaul C OrbanMajid MojibianC Bruce VerchereBrian T FifeMegan K Levings

Published in: bioRxiv : the preprint server for biology (2023)

Chimeric antigen receptor Tregs specific for an insulin B-chain peptide presented by MHC class II prevent autoimmune diabetes.

Keyphrases

type diabetes
glycemic control
cardiovascular disease
multiple sclerosis
insulin resistance
drug induced
weight loss
metabolic syndrome
skeletal muscle