Megan K Levings (M K Levings)

Loop profile Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 43

Top Venues

European journal of immunology

bioRxiv : the preprint server for biology

Diabetologia

medRxiv : the preprint server for health sciences

University of British Columbia

University of British Columbia (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of British Columbia

Canada

Professor :: Biomedical Engineering

BC Children's Hospital Research Institute

Canada

Theme Leader :: Childhood Diseases

University of British Columbia Jan 01 2003

Canada

Professor :: Surgery

Education History

University of British Columbia

Canada

PHD :: Genetics

Simon Fraser University

Canada

BSC :: Biology

Publications

Christine M Wardell, Vivian C W Fung, Eleanor Chen, Manjurul Haque, Jana Gillies, Justin A Spanier, Majid Mojibian, Brian T Fife, Megan K Levings
CAR Tregs mediate linked suppression and infectious tolerance in islet transplantation. bioRxiv : the preprint server for biology (2024)
Sabine Ivison, Gabrielle Boucher, Grace Zheng, Rosa V Garcia, Rita Kohen, Alain Bitton, John D Rioux, Megan K Levings, null null
Improving Reliability of Immunological Assays by Defining Minimal Criteria for Cell Fitness. ImmunoHorizons 8 (9) (2024)
Karoliina Tuomela, Megan K Levings
Genetic engineering of regulatory T cells for treatment of autoimmune disorders including type 1 diabetes. Diabetologia (2024)
Bao Khanh Trang, Prabhat Sharma, Laura Cook, Zachary Mount, Rajan M Thomas, Nikhil N Kulkarni, Matthew C Pahl, James A Pippin, Chun Su, Klaus H Kaestner, Joan M O'Brien, Yadav Wagley, Kurt D Hankenson, Ashley Jermusyk, Jason W Hoskins, Laufey T Amundadottir, Mai Xu, Kevin K Brown, Stewart A Anderson, Wenli Yang, Paul M Titchenell, Patrick Seale, Babette S Zemel, Alessandra Chesi, Neil Romberg, Megan K Levings, Struan F A Grant, Andrew D Wells
3D chromatin-based variant-to-gene maps across 57 human cell types reveal the cellular and genetic architecture of autoimmune disease susceptibility. medRxiv : the preprint server for health sciences (2024)
Christine M Wardell, Vivian C W Fung, Eleanor Chen, Manjurul Haque, Jana Gillies, Justin A Spanier, Majid Mojibian, Brian T Fife, Megan K Levings
Short Report: CAR Tregs mediate linked suppression and infectious tolerance in islet transplantation. bioRxiv : the preprint server for biology (2024)
Danijela Tatovic, Ashish Marwaha, Peter Taylor, Stephanie J Hanna, Kym Carter, Wai Yee Cheung, Steve Luzio, Gareth Dunseath, Hayley Anne Hutchings, Gail Holland, Steve Hiles, Gregory W Fegan, Evangelia Williams, Jennie Hsiu Mien Yang, Clara Domingo-Vila, Emily Pollock, Muntaha Wadud, Kirsten Ward-Hartstonge, Susie Marques-Jones, Jane Bowen-Morris, Rachel Stenson, Megan K Levings, John W Gregory, Timothy I M Tree, Colin Dayan, null null
Ustekinumab for type 1 diabetes in adolescents: a multicenter, double-blind, randomized phase 2 trial. Nature medicine (2024)
Christine M Wardell, Vivian C W Fung, Eleanor Chen, Manjurul Haque, Jana Gillies, Justin A Spanier, Majid Mojibian, Brian T Fife, Megan K Levings
Short Report: CAR Tregs mediate linked suppression and infectious tolerance in islet transplantation. bioRxiv : the preprint server for biology (2024)
Karoliina Tuomela, Megan K Levings
Genetic engineering of regulatory T cells for treatment of autoimmune disorders including type 1 diabetes. Diabetologia 67 (4) (2024)
Bao Khanh Trang, Prabhat Sharma, Laura Cook, Zachary Mount, Rajan M Thomas, Nikhil N Kulkarni, Matthew C Pahl, James A Pippin, Chun Su, Klaus H Kaestner, Joan M O'Brien, Yadav Wagley, Kurt D Hankenson, Ashley Jermusyk, Jason W Hoskins, Laufey T Amundadottir, Mai Xu, Kevin K Brown, Stewart A Anderson, Wenli Yang, Paul M Titchenell, Patrick Seale, Babette S Zemel, Alessandra Chesi, Neil Romberg, Megan K Levings, Struan F A Grant, Andrew D Wells
3D chromatin-based variant-to-gene maps across 57 human cell types reveal the cellular and genetic architecture of autoimmune disease susceptibility. medRxiv : the preprint server for health sciences (2024)
Karoliina Tuomela, Megan K Levings
Genetic engineering of regulatory T cells for treatment of autoimmune disorders including type 1 diabetes. Diabetologia 67 (4) (2024)
Christine M Wardell, Vivian C W Fung, Eleanor Chen, Manjurul Haque, Jana Gillies, Justin A Spanier, Majid Mojibian, Brian T Fife, Megan K Levings
Short Report: CAR Tregs mediate linked suppression and infectious tolerance in islet transplantation. bioRxiv : the preprint server for biology (2024)
Christine M Wardell, Vivian C W Fung, Eleanor Chen, Manjurul Haque, Jana Gillies, Justin A Spanier, Majid Mojibian, Brian T Fife, Megan K Levings
CAR Tregs mediate linked suppression and infectious tolerance in islet transplantation. bioRxiv : the preprint server for biology (2024)
Cara E Ellis, Majid Mojibian, Shogo Ida, Vivian C W Fung, Søs Skovsø, Emma McIver, Shannon O'Dwyer, Travis D Webber, Mitchell J S Braam, Nelly Saber, Timothy J Kieffer, Megan K Levings
Human A2-CAR T cells reject HLA-A2+ human islets transplanted into mice without inducing graft versus host disease. bioRxiv : the preprint server for biology (2023)
Cara E Ellis, Majid Mojibian, Shogo Ida, Vivian C W Fung, Søs Skovsø, Emma McIver, Shannon O'Dwyer, Travis D Webber, Mitchell J S Braam, Nelly Saber, Timothy J Kieffer, Megan K Levings
Human A2-CAR T cells reject HLA-A2+ human islets transplanted into mice without inducing graft versus host disease. bioRxiv : the preprint server for biology (2023)
Karoliina Tuomela, Megan K Levings
Acidity promotes the differentiation of immunosuppressive regulatory T cells. European journal of immunology (2023)
Esther Bernaldo-de-Quirós, Manuela Camino, Marta Martínez-Bonet, Juan Miguel Gil-Jaurena, Nuria Gil, Diana Carolina Hernández-Flórez, María-Eugenia Fernández-Santos, Laura Butragueño Laiseca, I Esmé Dijke, Megan K Levings, Lori J West, Marjorie Pion, Rafael Correa-Rocha
First-in-human therapy with Treg produced from thymic tissue (thyTreg) in a heart transplant infant. The Journal of experimental medicine 220 (12) (2023)
Karoliina Tuomela, Megan K Levings
Acidity promotes the differentiation of immunosuppressive regulatory T cells. European journal of immunology (2023)
Karoliina Tuomela, Kevin Salim, Megan K Levings
Eras of designer Tregs: Harnessing synthetic biology for immune suppression. Immunological reviews (2023)
Karoliina Tuomela, Megan K Levings
Acidity promotes the differentiation of immunosuppressive regulatory T cells. European journal of immunology (2023)
Justin A Spanier, Vivian Fung, Christine M Wardell, Mohannad H Alkhatib, Yixin Chen, Linnea A Swanson, Alexander J Dwyer, Matthew E Weno, Nubia Silva, Jason S Mitchell, Paul C Orban, Majid Mojibian, C Bruce Verchere, Brian T Fife, Megan K Levings
Insulin B peptide-MHC class II-specific chimeric antigen receptor-Tregs prevent autoimmune diabetes. bioRxiv : the preprint server for biology (2023)
Torin Halvorson, Karoliina Tuomela, Megan K Levings
Targeting regulatory T cell metabolism in disease: novel therapeutic opportunities. European journal of immunology (2023)
Caroline Lamarche, Kirsten A Ward-Hartstonge, Tian Mi, David T S Lin, Qing Huang, Andrew Brown, Karlie Edwards, Gherman E Novakovsky, Christopher N Qi, Michael S Kobor, Caitlin C Zebley, Evan W Weber, Crystal L Mackall, Megan K Levings
Tonic-signaling chimeric antigen receptors drive human regulatory T cell exhaustion. Proceedings of the National Academy of Sciences of the United States of America 120 (14) (2023)
Karoliina Tuomela, Megan K Levings
Acidity promotes the differentiation of immunosuppressive regulatory T cells. European journal of immunology (2023)
Caroline Lamarche, Kirsten A Ward-Hartstonge, Tian Mi, David T S Lin, Qing Huang, Andrew Brown, Karlie Edwards, Gherman E Novakovsky, Christopher N Qi, Michael S Kobor, Caitlin C Zebley, Evan W Weber, Crystal L Mackall, Megan K Levings
Tonic-signaling chimeric antigen receptors drive human regulatory T cell exhaustion. Proceedings of the National Academy of Sciences of the United States of America 120 (14) (2023)
Justin A Spanier, Vivian Fung, Christine M Wardell, Mohannad H Alkhatib, Yixin Chen, Linnea A Swanson, Alexander J Dwyer, Matthew E Weno, Nubia Silva, Jason S Mitchell, Paul C Orban, Majid Mojibian, C Bruce Verchere, Brian T Fife, Megan K Levings
Insulin B peptide-MHC class II-specific chimeric antigen receptor-Tregs prevent autoimmune diabetes. bioRxiv : the preprint server for biology (2023)
Jennie H M Yang, Kirsten A Ward-Hartstonge, Daniel J Perry, J Lori Blanchfield, Amanda L Posgai, Alice E Wiedeman, Kirsten Diggins, Adeeb Rahman, Timothy I M Tree, Todd M Brusko, Megan K Levings, Eddie A James, Sally C Kent, Cate Speake, Dirk Homann, S Alice Long, null null
Guidelines for standardizing T-cell cytometry assays to link biomarkers, mechanisms, and disease outcomes in type 1 diabetes. European journal of immunology 52 (3) (2022)
Emma Proics, Marion David, Majid Mojibian, Madeline Speck, Nadia Lounnas-Mourey, Adeline Govehovitch, Wissam Baghdadi, Justine Desnouveaux, Hervé Bastian, Laura Freschi, Geoffrey Privat, Cédric Pouzet, Mauro Grossi, Pierre Heimendinger, Tobias Abel, David Fenard, Megan K Levings, François Meyer, Céline Dumont
Preclinical assessment of antigen-specific chimeric antigen receptor regulatory T cells for use in solid organ transplantation. Gene therapy (2022)
Avery J Lam, Manjurul Haque, Kirsten A Ward-Hartstonge, Prakruti Uday, Christine M Wardell, Jana K Gillies, Madeleine Speck, Majid Mojibian, Ramon I Klein Geltink, Megan K Levings
PTEN is required for human Treg suppression of costimulation in vitro. European journal of immunology 52 (9) (2022)
M Battaglia, J H Buckner, Megan K Levings, S J Richardson, Florence Susan Wong, T I Tree
Identifying the 'Achilles heel' of type 1 diabetes. Clinical and experimental immunology 204 (2) (2021)
Erika M J Siren, Haiming D Luo, Franklin Tam, Ashani Montgomery, Winnie Enns, Haisle Moon, Lyann Sim, Kevin Rey, Qiunong Guan, Jiao-Jing Wang, Christine M Wardell, Mahdis Monajemi, Majid Mojibian, Megan K Levings, Zheng Jenny Zhang, Caigan Du, Stephen G Withers, Jonathan C Choy, Jayachandran N Kizhakkedathu
Prevention of vascular-allograft rejection by protecting the endothelial glycocalyx with immunosuppressive polymers. Nature biomedical engineering 5 (10) (2021)
Laura Cook, Kyle T Reid, Elmeri Häkkinen, Brett de Bie, Shigeru Tanaka, Danielle J Smyth, Madeleine P J White, May Q Wong, Qing Huang, Jana K Gillies, Steven F Ziegler, Rick M Maizels, Megan K Levings
Induction of stable human FOXP3+ Tregs by a parasite-derived TGF-β mimic. Immunology and cell biology 99 (8) (2021)
Christine M Wardell, Megan K Levings
mRNA vaccines take on immune tolerance. Nature biotechnology 39 (4) (2021)
Matthew A Budd, Mahdis Monajemi, Sarah J Colpitts, Sarah Q Crome, C Bruce Verchere, Megan K Levings
Interactions between islets and regulatory immune cells in health and type 1 diabetes. Diabetologia 64 (11) (2021)
Avery J Lam, Prakruti Uday, Jana K Gillies, Megan K Levings
Helios is a marker, not a driver, of human Treg stability. European journal of immunology (2021)
Nicholas A J Dawson, Isaac Rosado-Sánchez, Gherman E Novakovsky, Vivian C W Fung, Qing Huang, Emma McIver, Grace Sun, Jana Gillies, Madeleine Speck, Paul C Orban, Majid Mojibian, Megan K Levings
Functional effects of chimeric antigen receptor co-receptor signaling domains in human regulatory T cells. Science translational medicine 12 (557) (2021)
Dominic A Boardman, Rosa V Garcia, Sabine M Ivison, Brian Bressler, Tg Murali Dhar, Qihong Zhao, Megan K Levings
Pharmacological inhibition of RORC2 enhances human Th17-Treg stability and function. European journal of immunology 50 (9) (2020)
Antoine Sicard, Caroline Lamarche, Madeleine Speck, May Wong, Isaac Rosado-Sánchez, Mathilde Blois, Nicolas Glaichenhaus, Majid Mojibian, Megan K Levings
Donor-specific chimeric antigen receptor Tregs limit rejection in naive but not sensitized allograft recipients. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20 (6) (2020)
Christine M Wardell, Katherine N MacDonald, Megan K Levings, Laura Cook
Cross talk between human regulatory T cells and antigen-presenting cells: Lessons for clinical applications. European journal of immunology 51 (1) (2020)
Dan Wu, Jonathan M Han, Xin Yu, Avery J Lam, Romy E Hoeppli, Anne M Pesenacker, Qing Huang, Virginia Chen, Cate Speake, Ekua Yorke, Nam Nguyen, Sharadh Sampath, David Harris, Megan K Levings
Characterization of regulatory T cells in obese omental adipose tissue in humans. European journal of immunology 49 (2) (2019)
Dan Wu, Qing Huang, Paul C Orban, Megan K Levings
Ectopic germline recombination activity of the widely used Foxp3-YFP-Cre mouse: a case report. Immunology 159 (2) (2019)
Avery J Lam, Katherine N MacDonald, Anne Maria Pesenacker, Stephen C Juvet, Kimberly A Morishita, Brian Bressler, null null, James G Pan, Sachdev S Sidhu, John D Rioux, Megan K Levings
Innate Control of Tissue-Reparative Human Regulatory T Cells. Journal of immunology (Baltimore, Md. : 1950) 202 (8) (2019)
K N MacDonald, J M Piret, Megan K Levings
Methods to manufacture regulatory T cells for cell therapy. Clinical and experimental immunology 197 (1) (2019)
Nicholas A J Dawson, Avery J Lam, Laura Cook, Romy E Hoeppli, Raewyn Broady, Anne M Pesenacker, Megan K Levings
An optimized method to measure human FOXP3+ regulatory T cells from multiple tissue types using mass cytometry. European journal of immunology 48 (8) (2018)

Megan K Levings.css-eqlu8i{font-size:small;padding-left:4px;} (M K Levings)

Publication Activity (10 Years)

Top Topics

Top Venues

Megan K Levings (M K Levings)