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Cathepsins Trigger Cell Death and Regulate Radioresistance in Glioblastoma.

Xiaofeng DingChen ZhangHuajian ChenMing-Hua RenXiaodong Liu
Published in: Cells (2022)
Treatment of glioblastoma (GBM) remains very challenging, and it is particularly important to find sensitive and specific molecular targets. In this work, we reveal the relationship between the expression of cathepsins and radioresistance in GBM. We analyzed cathepsins (cathepsin B, cathepsin D, cathepsin L, and cathepsin Z/X), which are highly associated with the radioresistance of GBM by regulating different types of cell death. Cathepsins could be potential targets for GBM treatment.
Keyphrases
  • cell death
  • poor prognosis
  • gene expression
  • single cell
  • cancer stem cells
  • genome wide
  • cell proliferation
  • risk assessment
  • cell cycle arrest
  • dna methylation
  • oxidative stress
  • signaling pathway
  • pi k akt