LncRNA-miRNA-mRNA Network Analysis Reveals the Potential Biomarkers in Crohn's Disease Rats Treated with Herb-Partitioned Moxibustion.
Xue-Jun WangXiao-Ying LiXiao-Cong GuoLi LiuYou-You JinYun-Qiong LuYao-Jia-Ni CaoJun-Yi LongHuan-Gan WuDan ZhangGuang YangJue HongYan-Ting YangXiao-Peng MaPublished in: Journal of inflammation research (2022)
By constructing a ceRNA network with lncRNA-miRNA-mRNA, PCR verification, and KEGG analysis, we revealed that LOC102550026/miRNA-34c-5p/Pck1 axis and adipocytokine, PPAR, AMPK, FoxO, and PI3K-Akt signaling pathways might regulate the intestinal immune-inflammatory response, and HPM may regulate the lncRNA LOC102550026/miR-34c-5p/Pck1 axis and adipocytokine, PPAR, AMPK, FoxO, and PI3K-Akt signaling pathways, thus improving intestinal inflammation in CD. These findings may be novel potential targets in CD.
Keyphrases
- pi k akt
- long non coding rna
- signaling pathway
- network analysis
- cell proliferation
- long noncoding rna
- inflammatory response
- cell cycle arrest
- skeletal muscle
- insulin resistance
- epithelial mesenchymal transition
- protein kinase
- fatty acid
- lipopolysaccharide induced
- binding protein
- type diabetes
- lps induced
- single cell
- risk assessment
- data analysis