A Comprehensive Review of the Potential Role of Liquid Biopsy as a Diagnostic, Prognostic, and Predictive Biomarker in Pancreatic Ductal Adenocarcinoma.
Kosta StosicOier Azurmendi SenarJawad TarfoussChristelle BouchartJulie NavezJean-Luc Van LaethemTatjana ArsenijevicPublished in: Cells (2023)
Pancreatic ductal adenocarcinoma is one of the most lethal malignant diseases, with a mortality rate being close to incidence. Due to its heterogeneity and plasticity, as well as the lack of distinct symptoms in the early phases, it is very often diagnosed at an advanced stage, resulting in poor prognosis. Traditional tissue biopsies remain the gold standard for making a diagnosis, but have an obvious disadvantage in their inapplicability for frequent sampling. Blood-based biopsies represent a non-invasive method which potentially offers easy and repeated sampling, leading to the early detection and real-time monitoring of the disease and hopefully an accurate prognosis. Given the urgent need for a reliable biomarker that can estimate a patient's condition and response to an assigned treatment, blood-based biopsies are emerging as a potential new tool for improving patients' survival and surveillance. In this article, we discuss the current advances and challenges in using liquid biopsies for pancreatic cancer, focusing on circulating tumour DNA (ctDNA), extracellular vesicles (EVs), and circulating tumour cells (CTCs), and compare the performance and reliability of different biomarkers and combinations of biomarkers.
Keyphrases
- poor prognosis
- ultrasound guided
- long non coding rna
- end stage renal disease
- circulating tumor
- induced apoptosis
- ejection fraction
- risk factors
- public health
- chronic kidney disease
- cardiovascular events
- ionic liquid
- prognostic factors
- fine needle aspiration
- circulating tumor cells
- cell cycle arrest
- case report
- single cell
- cardiovascular disease
- risk assessment
- coronary artery disease
- patient reported outcomes
- oxidative stress
- depressive symptoms
- cell death
- sleep quality
- silver nanoparticles