Regenerative Medicine for Axial and Radicular Spine-Related Pain: A Narrative Review.

Mehul J DesaiJohn Taylor Mansfield David M RobinsonBenjamin C MillerJoanne Borg-Stein

Published in: Pain practice : the official journal of World Institute of Pain (2020)

Currently, there are level I studies to support the use of PRP and MSC injections for discogenic pain; facet joint injections with PRP; epidural injections of autologous conditioned serum and epidural prolotherapy; and PRP and prolotherapy for sacroiliac joint pain. One level I study showed that facet joint prolotherapy has no significant benefit. Notably, no intervention has multiple published level I studies.

Keyphrases

platelet rich plasma
chronic pain
pain management
neuropathic pain
spinal cord
randomized controlled trial
ultrasound guided
case control
systematic review
bone marrow
stem cells
mesenchymal stem cells
cell therapy
drug induced
meta analyses
postoperative pain