A human PET study of [11C]HMS011, a potential radioligand for AMPA receptors.

Keisuke TakahataYasuyuki KimuraChie SekiMasaki TokunagaMasanori IchiseKazunori KawamuraMaiko OnoSoichiro KitamuraManabu KubotaSho MoriguchiTatsuya IshiiYuhei TakadoFumitoshi NiwaHironobu EndoTomohisa NagashimaYoko IkomaMing-Rong ZhangTetsuya SuharaMakoto Higuchi

Published in: EJNMMI research (2017)

Kinetic analyses support some specific binding of [11C]HMS011 in the human cortex. However, this ligand may not be suitable for practical AMPA receptor PET imaging due to the small dynamic range and metabolite in the brain.

Keyphrases

pet imaging
endothelial cells
induced pluripotent stem cells
pluripotent stem cells
positron emission tomography
computed tomography
functional connectivity
resting state
multiple sclerosis
risk assessment
human health
brain injury
transcription factor
dna binding