Genomic profiling of metastatic castration-resistant prostate cancer samples resistant to androgen-receptor pathway inhibitors.
Naoual MenssouriLoic PoiraudeauCarole HelisseyLudovic BigotJonathan SabioTony IbrahimCedric PobelClaudio NicotraMaud Ngo-CamusLudovic LacroixEtienne RouleauLambros TselikasAnne ChauchereauFélix Blanc-DurandAlice Bernard-TessierAnna PatrikidouNatacha NaounRonan FlippotEmeline ColombaAlina FuereaLaurence AlbigesPernelle LavaudPaul van de WielEveline den Biezen-TimmermansYvonne J W RozendaalSantiago Ponce-AixStefan MichielsChristophe MassardDaniel GautheretFabrice BarlesiFabrice AndreBenjamin BesseJean Yves ScoazecLuc FribouletKarim FizaziYohann LoriotPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
Low AR activity, activation of stemness programs, and Hedgehog pathway were associated with primary ARPIs' resistance, whereas most acquired resistance was associated with subclonal evolution, AR-related events, and neuroendocrine differentiation.