IL11 (Interleukin-11) Causes Emphysematous Lung Disease in a Mouse Model of Marfan Syndrome.

Benjamin NgChen XieLiping SuFathima F KuthubudeenXiu-Yi KwekDaryl YeongChee Jian Pua Stuart Alexander Cook Wei Wen Lim

Published in: Arteriosclerosis, thrombosis, and vascular biology (2023)

IL11 causes lung disease in mMFS. This reveals a shared IL11-driven disease mechanism in lung and aorta in MFS and suggests inhibition of IL11 signaling as a holistic approach for treating multiorgan morbidity in MFS.

Keyphrases

mouse model
pulmonary artery
coronary artery
aortic dissection