Stuart Alexander Cook (Stuart Cook, Stuart A Cook)

Publication Activity (10 Years)

Years Active: 2019-2024
Publications (10 Years): 37

Top Topics

Ejection Fraction

Idiopathic Pulmonary Fibrosis

Top Venues

Nature communications

Circulation. Genomic and precision medicine

Science translational medicine

This page only lists publications with an associated author ORCID identifier.

Publications

Anissa Anindya Widjaja, Wei Wen Lim, Sivakumar Viswanathan, Sonia Chothani, Ben Corden, Cibi Mary Dasan, Joyce Wei Ting Goh, Radiance Lim, Brijesh Kumar Singh, Jessie Tan, Chee Jian Pua, Sze Yun Lim, Eleonora Adami, Sebastian Schafer, Benjamin L George, Mark Sweeney, Chen Xie, Madhulika Tripathi, Natalie A Sims, Norbert Hübner, Enrico Petretto, Dominic J Withers, Lena Ho, Jesús Gil, David Carling, Stuart Alexander Cook
Inhibition of IL-11 signalling extends mammalian healthspan and lifespan. Nature (2024)
Anissa Anindya Widjaja, Wei Wen Lim, Sivakumar Viswanathan, Sonia Chothani, Ben Corden, Cibi Mary Dasan, Joyce Wei Ting Goh, Radiance Lim, Brijesh Kumar Singh, Jessie Tan, Chee Jian Pua, Sze Yun Lim, Eleonora Adami, Sebastian Schafer, Benjamin L George, Mark Sweeney, Chen Xie, Madhulika Tripathi, Natalie A Sims, Norbert Hübner, Enrico Petretto, Dominic J Withers, Lena Ho, Jesús Gil, David Carling, Stuart Alexander Cook
Inhibition of IL-11 signalling extends mammalian healthspan and lifespan. Nature 632 (8023) (2024)
Anissa Anindya Widjaja, Wei Wen Lim, Sivakumar Viswanathan, Sonia Chothani, Ben Corden, Cibi Mary Dasan, Joyce Wei Ting Goh, Radiance Lim, Brijesh Kumar Singh, Jessie Tan, Chee Jian Pua, Sze Yun Lim, Eleonora Adami, Sebastian Schafer, Benjamin L George, Mark Sweeney, Chen Xie, Madhulika Tripathi, Natalie A Sims, Norbert Hübner, Enrico Petretto, Dominic J Withers, Lena Ho, Jesús Gil, David Carling, Stuart Alexander Cook
Inhibition of IL-11 signalling extends mammalian healthspan and lifespan. Nature 632 (8023) (2024)
Anissa Anindya Widjaja, Wei Wen Lim, Sivakumar Viswanathan, Sonia Chothani, Ben Corden, Cibi Mary Dasan, Joyce Wei Ting Goh, Radiance Lim, Brijesh Kumar Singh, Jessie Tan, Chee Jian Pua, Sze Yun Lim, Eleonora Adami, Sebastian Schafer, Benjamin L George, Mark Sweeney, Chen Xie, Madhulika Tripathi, Natalie A Sims, Norbert Hübner, Enrico Petretto, Dominic J Withers, Lena Ho, Jesús Gil, David Carling, Stuart Alexander Cook
Inhibition of IL-11 signalling extends mammalian healthspan and lifespan. Nature 632 (8023) (2024)
Anissa Anindya Widjaja, Wei Wen Lim, Sivakumar Viswanathan, Sonia Chothani, Ben Corden, Cibi Mary Dasan, Joyce Wei Ting Goh, Radiance Lim, Brijesh Kumar Singh, Jessie Tan, Chee Jian Pua, Sze Yun Lim, Eleonora Adami, Sebastian Schafer, Benjamin L George, Mark Sweeney, Chen Xie, Madhulika Tripathi, Natalie A Sims, Norbert Hübner, Enrico Petretto, Dominic J Withers, Lena Ho, Jesús Gil, David Carling, Stuart Alexander Cook
Inhibition of IL-11 signalling extends mammalian healthspan and lifespan. Nature 632 (8023) (2024)
Anissa Anindya Widjaja, Wei Wen Lim, Sivakumar Viswanathan, Sonia Chothani, Ben Corden, Cibi Mary Dasan, Joyce Wei Ting Goh, Radiance Lim, Brijesh Kumar Singh, Jessie Tan, Chee Jian Pua, Sze Yun Lim, Eleonora Adami, Sebastian Schafer, Benjamin L George, Mark Sweeney, Chen Xie, Madhulika Tripathi, Natalie A Sims, Norbert Hübner, Enrico Petretto, Dominic J Withers, Lena Ho, Jesús Gil, David Carling, Stuart Alexander Cook
Inhibition of IL-11 signalling extends mammalian healthspan and lifespan. Nature 632 (8023) (2024)
Anissa Anindya Widjaja, Wei Wen Lim, Sivakumar Viswanathan, Sonia Chothani, Ben Corden, Cibi Mary Dasan, Joyce Wei Ting Goh, Radiance Lim, Brijesh Kumar Singh, Jessie Tan, Chee Jian Pua, Sze Yun Lim, Eleonora Adami, Sebastian Schafer, Benjamin L George, Mark Sweeney, Chen Xie, Madhulika Tripathi, Natalie A Sims, Norbert Hübner, Enrico Petretto, Dominic J Withers, Lena Ho, Jesús Gil, David Carling, Stuart Alexander Cook
Inhibition of IL-11 signalling extends mammalian healthspan and lifespan. Nature 632 (8023) (2024)
Anissa Anindya Widjaja, Wei Wen Lim, Sivakumar Viswanathan, Sonia Chothani, Ben Corden, Cibi Mary Dasan, Joyce Wei Ting Goh, Radiance Lim, Brijesh Kumar Singh, Jessie Tan, Chee Jian Pua, Sze Yun Lim, Eleonora Adami, Sebastian Schafer, Benjamin L George, Mark Sweeney, Chen Xie, Madhulika Tripathi, Natalie A Sims, Norbert Hübner, Enrico Petretto, Dominic J Withers, Lena Ho, Jesús Gil, David Carling, Stuart Alexander Cook
Inhibition of IL-11 signalling extends mammalian healthspan and lifespan. Nature (2024)
Anissa Anindya Widjaja, Wei Wen Lim, Sivakumar Viswanathan, Sonia Chothani, Ben Corden, Cibi Mary Dasan, Joyce Wei Ting Goh, Radiance Lim, Brijesh Kumar Singh, Jessie Tan, Chee Jian Pua, Sze Yun Lim, Eleonora Adami, Sebastian Schafer, Benjamin L George, Mark Sweeney, Chen Xie, Madhulika Tripathi, Natalie A Sims, Norbert Hübner, Enrico Petretto, Dominic J Withers, Lena Ho, Jesús Gil, David Carling, Stuart Alexander Cook
Inhibition of IL-11 signalling extends mammalian healthspan and lifespan. Nature 632 (8023) (2024)
Stuart Alexander Cook
The Pathobiology of Interleukin 11 in Mammalian Disease is Likely Explained by its Essential Evolutionary Role for Fin Regeneration. Journal of cardiovascular translational research (2023)
Lara Curran, Antonio de Marvao, Paolo Inglese, Kathryn Anne McGurk, Pierre-Raphaël Schiratti, Adam Clement, Sean L Zheng, Surui Li, Chee Jian Pua, Mit Shah, Mina Jafari, Pantazis I Theotokis, Rachel J Buchan, Sean Joseph Jurgens, Claire E Raphael, Arun John Baksi, Antonis Pantazis, Brian P Halliday, Dudley John Pennell, Wenjia Bai, Calvin Woon-Loong Chin, Rafik Tadros, Connie R Bezzina, Hugh C Watkins, Stuart Alexander Cook, Sanjay K Prasad, James Simon Ware, Declan P O'Regan
Genotype-Phenotype Taxonomy of Hypertrophic Cardiomyopathy. Circulation. Genomic and precision medicine (2023)
Benjamin Ng, Chen Xie, Liping Su, Fathima F Kuthubudeen, Xiu-Yi Kwek, Daryl Yeong, Chee Jian Pua, Stuart Alexander Cook, Wei Wen Lim
IL11 (Interleukin-11) Causes Emphysematous Lung Disease in a Mouse Model of Marfan Syndrome. Arteriosclerosis, thrombosis, and vascular biology (2023)
Stuart Alexander Cook
The Pathobiology of Interleukin 11 in Mammalian Disease is Likely Explained by its Essential Evolutionary Role for Fin Regeneration. Journal of cardiovascular translational research (2023)
Chee Jian Pua, Germaine Loo, Michelle Kui, Wai Lun Moy, An-An Hii, Vivian Lee, Chee-Tang Chin, Jennifer A Bryant, Desiree-Faye Toh, Chi-Hang Lee, Stuart Alexander Cook, Arthur Mark Richards, Thu-Thao Le, Calvin Woon-Loong Chin
Impact of Diabetes on Myocardial Fibrosis in Patients With Hypertension: The REMODEL Study. Circulation. Cardiovascular imaging (2023)
Stuart Alexander Cook
Understanding interleukin 11 as a disease gene and therapeutic target. The Biochemical journal 480 (23) (2023)
Weizhuang Zhou, Yu En Chan, Chuan Sheng Foo, Jingxian Zhang, Jing Xian Teo, Sonia Davila, Weiting Huang, Jonathan J L Yap, Stuart Alexander Cook, Patrick Boon-Ooi Tan, Calvin Woon-Loong Chin, Khung Keong Yeo, Weng Khong Lim, Pavitra Krishnaswamy
High-Resolution Digital Phenotypes From Consumer Wearables and Their Applications in Machine Learning of Cardiometabolic Risk Markers: Cohort Study. Journal of medical Internet research 24 (7) (2022)
Nithin R Iyer, Thu-Thao Le, Michelle S L Kui, Hak-Chiaw Tang, Chee-Tang Chin, Soon-Kieng Phua, Jennifer A Bryant, Chee Jian Pua, Briana Ang, Desiree-Faye Toh, Tar-Choon Aw, Chi-Hang Lee, Stuart Alexander Cook, Martin Ugander, Calvin Woon-Loong Chin
Markers of Focal and Diffuse Nonischemic Myocardial Fibrosis Are Associated With Adverse Cardiac Remodeling and Prognosis in Patients With Hypertension: The REMODEL Study. Hypertension (Dallas, Tex. : 1979) 79 (8) (2022)
Anissa Anindya Widjaja, Sivakumar Viswanathan, Shamini G Shekeran, Eleonora Adami, Wei Wen Lim, Sonia Chothani, Jessie Tan, Joyce Wei Ting Goh, Hui Mei Chen, Sze Yun Lim, Carine M Boustany-Kari, Julie Hawkins, Enrico Petretto, Norbert Hübner, Sebastian Schafer, Thomas M Coffman, Stuart Alexander Cook
Targeting endogenous kidney regeneration using anti-IL11 therapy in acute and chronic models of kidney disease. Nature communications 13 (1) (2022)
Jin Zhou, Jeremy Pang, Madhulika Tripathi, Jia Pei Ho, Anissa Anindya Widjaja, Shamini Guna Shekeran, Stuart Alexander Cook, Ayako Suzuki, Anna Mae Diehl, Enrico Petretto, Brijesh Kumar Singh, Paul Michael Yen
Spermidine-mediated hypusination of translation factor EIF5A improves mitochondrial fatty acid oxidation and prevents non-alcoholic steatohepatitis progression. Nature communications 13 (1) (2022)
Wei Wen Lim, Jinrui Dong, Benjamin Ng, Anissa Anindya Widjaja, Chen Xie, Liping Su, Xiu-Yi Kwek, Nicole G Z Tee, Chee Jian Pua, Sebastian Schafer, Sivakumar Viswanathan, Stuart Alexander Cook
Inhibition of IL11 Signaling Reduces Aortic Pathology in Murine Marfan Syndrome. Circulation research 130 (5) (2022)
Nicola Whiffin, Konrad J Karczewski, Xiaolei Zhang, Sonia Chothani, Miriam J Smith, D Gareth Evans, Angharad M Roberts, Nicholas M Quaife, Sebastian Schafer, Owen Rackham, Jessica Alfoldi, Anne H O'Donnell-Luria, Laurent C Francioli, null null, null null, Stuart Alexander Cook, Paul J R Barton, Daniel G MacArthur, James Simon Ware
Author Correction: Characterising the loss-of-function impact of 5' untranslated region variants in 15,708 individuals. Nature communications 12 (1) (2021)
Jinrui Dong, Sivakumar Viswanathan, Eleonora Adami, Brijesh K Singh, Sonia P Chothani, Benjamin Ng, Wei Wen Lim, Jin Zhou, Madhulika Tripathi, Nicole S J Ko, Shamini G Shekeran, Jessie Tan, Sze Yun Lim, Mao Wang, Pei Min Lio, Paul M Yen, Sebastian Schafer, Stuart Alexander Cook, Anissa Anindya Widjaja
Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH. Nature communications 12 (1) (2021)
Parth N Patel, Shefali S Verma, Jon A L Willcox, Alireza Haghighi, Min Young Jang, Joshua M Gorham, Steven R DePalma, Lien Lam, Barbara McDonough, Renee Johnson, Neal K Lakdawala, Amy E Roberts, Paul J R Barton, Stuart Alexander Cook, Diane Fatkin, Christine E Seidman, Jonathan G Seidman
Contribution of Noncanonical Splice Variants to TTN Truncating Variant Cardiomyopathy. Circulation. Genomic and precision medicine 14 (5) (2021)
Eleonora Adami, Sivakumar Viswanathan, Anissa A Widjaja, Benjamin Ng, Sonia Chothani, Nevin Zhihao, Jessie Tan, Pei Min Lio, Benjamin L George, Umut Altunoglu, Kakaly Ghosh, Bhairav S Paleja, Sebastian Schafer, Bruno Reversade, Salvatore Albani, Andrea Low Hsiu Ling, Steven O'Reilly, Stuart Alexander Cook
IL11 is elevated in systemic sclerosis and IL11-dependent ERK signalling underlies TGFβ-mediated activation of dermal fibroblasts. Rheumatology (Oxford, England) 60 (12) (2021)
Anissa Anindya Widjaja, Jinrui Dong, Eleonora Adami, Sivakumar Viswanathan, Benjamin Ng, Leroy S Pakkiri, Sonia P Chothani, Brijesh Kumar Singh, Wei Wen Lim, Jin Zhou, Shamini G Shekeran, Jessie Tan, Sze Yun Lim, Joyce Goh, Mao Wang, Robert Holgate, Arron Hearn, Leanne E Felkin, Paul M Yen, James W Dear, Chester Lee Drum, Sebastian Schafer, Stuart Alexander Cook
Redefining IL11 as a regeneration-limiting hepatotoxin and therapeutic target in acetaminophen-induced liver injury. Science translational medicine 13 (597) (2021)
Jinrui Dong, Sivakumar Viswanathan, Eleonora Adami, Sebastian Schafer, Fathima F Kuthubudeen, Anissa Anindya Widjaja, Stuart Alexander Cook
The pro-regenerative effects of hyperIL6 in drug-induced liver injury are unexpectedly due to competitive inhibition of IL11 signaling. eLife 10 (2021)
Wei Wen Lim, Ben Corden, Lei Ye, Sivakumar Viswanathan, Anissa Anindya Widjaja, Chen Xie, Liping Su, Nicole G Z Tee, Sebastian Schafer, Stuart Alexander Cook
Antibody-mediated neutralization of IL11 signalling reduces ERK activation and cardiac fibrosis in a mouse model of severe pressure overload. Clinical and experimental pharmacology & physiology 48 (4) (2021)
Nicola Whiffin, Konrad J Karczewski, Xiaolei Zhang, Sonia Chothani, Miriam J Smith, D Gareth Evans, Angharad M Roberts, Nicholas M Quaife, Sebastian Schafer, Owen Rackham, Jessica Alfoldi, Anne H O'Donnell-Luria, Laurent C Francioli, null null, null null, Stuart Alexander Cook, Paul J R Barton, Daniel G MacArthur, James Simon Ware
Characterising the loss-of-function impact of 5' untranslated region variants in 15,708 individuals. Nature communications 11 (1) (2020)
Alfred Xuyang Sun, Qiang Yuan, Masahiro Fukuda, Weonjin Yu, Haidun Yan, Grace Gui Yin Lim, Mui Hoon Nai, Giuseppe Alessandro D'Agostino, Hoang-Dai Tran, Yoko Itahana, Danlei Wang, Hidayat Lokman, Koji Itahana, Stephanie Wai Lin Lim, Jiong Tang, Ya Yin Chang, Menglan Zhang, Stuart Alexander Cook, Owen J L Rackham, Chwee-Teck Lim, Eng King Tan, Huck Hui Ng, Kah Leong Lim, Yong-Hui Jiang, Hyunsoo Shawn Je
Potassium channel dysfunction in human neuronal models of Angelman syndrome. Science (New York, N.Y.) 366 (6472) (2020)
Benjamin Ng, Jinrui Dong, Giuseppe Alessandro D'Agostino, Sivakumar Viswanathan, Anissa Anindya Widjaja, Wei Wen Lim, Nicole S J Ko, Jessie Tan, Sonia P Chothani, Benjamin Huang, Chen Xie, Chee Jian Pua, Ann-Marie Chacko, Nuno Guimarães-Camboa, Sylvia M Evans, Adam J Byrne, Toby M Maher, Jiurong Liang, Dianhua Jiang, Paul W Noble, Sebastian Schafer, Stuart Alexander Cook
Interleukin-11 is a therapeutic target in idiopathic pulmonary fibrosis. Science translational medicine 11 (511) (2020)
Anissa Anindya Widjaja, Sonia P Chothani, Stuart Alexander Cook
Different roles of interleukin 6 and interleukin 11 in the liver: implications for therapy. Human vaccines & immunotherapeutics 16 (10) (2020)
Mark Sweeney, Ben Corden, Stuart Alexander Cook
Targeting cardiac fibrosis in heart failure with preserved ejection fraction: mirage or miracle? EMBO molecular medicine 12 (10) (2020)
Najim Lahrouchi, Hariharan Raju, Elisabeth M Lodder, Stathis Papatheodorou, Chris Miles, James Simon Ware, Michael Papadakis, Rafik Tadros, Della Cole, Jonathan R Skinner, Jackie Crawford, Donald R Love, Chee J Pua, Bee Y Soh, Jaydutt D Bhalshankar, Risha Govind, Jacob Tfelt-Hansen, Bo G Winkel, Christian van der Werf, Yanushi D Wijeyeratne, Greg Mellor, Janice Till, Marta C Cohen, María Teresa Tomé-Esteban, Sanjay Sharma, Arthur A M Wilde, Stuart Alexander Cook, Mary N Sheppard, Connie R Bezzina, Elijah R Behr
The yield of postmortem genetic testing in sudden death cases with structural findings at autopsy. European journal of human genetics : EJHG 28 (1) (2019)
Jing Xian Teo, Sonia Davila, Chengxi Yang, An An Hii, Chee Jian Pua, Jonathan Yap, Swee Yaw Tan, Anders Sahlén, Calvin Woon-Loong Chin, Bin Tean Teh, Steven G Rozen, Stuart Alexander Cook, Khung Keong Yeo, Patrick Tan, Weng Khong Lim
Digital phenotyping by consumer wearables identifies sleep-associated markers of cardiovascular disease risk and biological aging. Communications biology 2 (2019)
Yasmin Bylstra, Sonia Davila, Weng Khong Lim, Ryanne Wu, Jing Xian Teo, Sylvia Kam, Tamra Lysaght, Steve Rozen, Bin Tean Teh, Khung Keong Yeo, Stuart Alexander Cook, Patrick Tan, Saumya Shekhar Jamuar
Implementation of genomics in medical practice to deliver precision medicine for an Asian population. NPJ genomic medicine 4 (2019)
Huimei Chen, Aida Moreno-Moral, Francesco Pesce, Nithya Devapragash, Massimiliano Mancini, Ee Ling Heng, Maxime Rotival, Prashant K Srivastava, Nathan Harmston, Kirill Shkura, Owen J L Rackham, Wei-Ping Yu, Xi-Ming Sun, Nicole Gui Zhen Tee, Elisabeth Li Sa Tan, Paul J R Barton, Leanne E Felkin, Enrique Lara-Pezzi, Gianni Angelini, Cristina Beltrami, Michal Pravenec, Sebastian Schafer, Leonardo Bottolo, Norbert Hubner, Costanza Emanueli, Stuart Alexander Cook, Enrico Petretto
WWP2 regulates pathological cardiac fibrosis by modulating SMAD2 signaling. Nature communications 10 (1) (2019)
Huimei Chen, Aida Moreno-Moral, Francesco Pesce, Nithya Devapragash, Massimiliano Mancini, Ee Ling Heng, Maxime Rotival, Prashant K Srivastava, Nathan Harmston, Kirill Shkura, Owen J L Rackham, Wei-Ping Yu, Xi-Ming Sun, Nicole Gui Zhen Tee, Elisabeth Li Sa Tan, Paul J R Barton, Leanne E Felkin, Enrique Lara-Pezzi, Gianni Angelini, Cristina Beltrami, Michal Pravenec, Sebastian Schafer, Leonardo Bottolo, Norbert Hubner, Costanza Emanueli, Stuart Alexander Cook, Enrico Petretto
Author Correction: WWP2 regulates pathological cardiac fibrosis by modulating SMAD2 signaling. Nature communications 10 (1) (2019)