Shear Stress Promotes Remodeling of Platelet Glycosylation via Upregulation of Platelet Glycosidase Activity: One More Thing.
Yana Roka-MoiiaSabrina LewisEstevan ClevelandJoseph ItalianoMarvin J SlepianPublished in: Thrombosis and haemostasis (2024)
Shear stress accumulation, consistent with supraphysiologic conditions of device-supported circulation, promotes remodeling of platelet glycosylation via selective upregulation of platelet glycosidase activity. Shear-mediated platelet deglycosylation is associated with platelet count drop and increased microvesiculation.