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Optimising plasma clozapine levels to improve treatment response: an individual patient data meta-analysis and receiver operating characteristic curve analysis.

Korinne NorthwoodE PearsonU ArnautovskaMeshary Khaled N AlotibyM PawarM SharmaK VitangcolE WagnerN WarrenDan J Siskind
Published in: The British journal of psychiatry : the journal of mental science (2023)
Clozapine dose should be optimised based on clozapine therapeutic levels. We found that a range between 250 and 550 ng/mL could be recommended, while noting that a level of >350 ng/mL is the most optimal for response. Although some patients may not respond without clozapine levels >550 ng/mL, the benefits should be weighed against the increased risk of adverse drug reactions.
Keyphrases
  • adverse drug
  • systematic review
  • end stage renal disease
  • electronic health record
  • ejection fraction
  • newly diagnosed
  • chronic kidney disease
  • peritoneal dialysis
  • prognostic factors
  • randomized controlled trial