Optimising plasma clozapine levels to improve treatment response: an individual patient data meta-analysis and receiver operating characteristic curve analysis.
Korinne NorthwoodE PearsonU ArnautovskaMeshary Khaled N AlotibyM PawarM SharmaK VitangcolE WagnerN WarrenDan J SiskindPublished in: The British journal of psychiatry : the journal of mental science (2023)
Clozapine dose should be optimised based on clozapine therapeutic levels. We found that a range between 250 and 550 ng/mL could be recommended, while noting that a level of >350 ng/mL is the most optimal for response. Although some patients may not respond without clozapine levels >550 ng/mL, the benefits should be weighed against the increased risk of adverse drug reactions.