The Role of Mitochondria-Linked Fatty-Acid Uptake-Driven Adipogenesis in Graves Orbitopathy.

Lei ZhangPavandeep RaiSatomi MiwaMohd Shazli DramanD Aled ReesAnjana S HaridasDaniel S MorrisAndrew R TeeMarian LudgateDoug M TurnbullColin M Dayan

Published in: Endocrinology (2022)

Our study confirmed that FA uptake can drive OAT adipogenesis and revealed a fundamental role for mitochondria-OXPHOS in GO development, which provides potential for therapeutic interventions.

Keyphrases

fatty acid
cell death
reactive oxygen species
endoplasmic reticulum
physical activity
high fat diet induced
single cell
type diabetes
metabolic syndrome
risk assessment
adipose tissue
skeletal muscle
insulin resistance
human health