Purine synthesis suppression reduces the development and progression of pulmonary hypertension in rodent models.

Qian MaQiuhua YangJiean XuHunter G SellersZach L BrownZhiping LiuZsuzsanna BordanXiaofan ShiDingwei ZhaoYongfeng CaiVidhi PareekChunxiang ZhangGuangyu WuZheng DongAlexander D VerinLin GanQuansheng DuStephen J BenkovicJianping WengJohn M AsaraIssam Ben-SahraScott BarmanYunchao SuDavid J R FultonYuqing Huo

Published in: European heart journal (2023)

Targeting ATIC-mediated DNPS compromises the availability of purine nucleotides for incorporation into DNA/RNA, reducing PASMC proliferation and pulmonary vascular remodelling and ameliorating the development and progression of PH.

Keyphrases

pulmonary hypertension
pulmonary artery
pulmonary arterial hypertension
signaling pathway
circulating tumor
nucleic acid
cancer therapy
coronary artery