Issam Ben-Sahra (I Ben-Sahra)

ORCID

Publication Activity (10 Years)

Years Active: 2019-2024
Publications (10 Years): 36

Top Venues

Science advances

Nature metabolism

Science (New York, N.Y.)

Cell death discovery

Northwestern University - Chicago

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Northwestern University - Chicago Jan 01 2017

United States

Assistant Professor :: Biochemistry and Molecular Genetics

Publications

Umakant Sahu, Elodie Villa, Colleen R Reczek, Zibo Zhao, Brendan P O'Hara, Michael D Torno, Rohan Mishra, William D Shannon, John M Asara, Peng Gao, Ali Shilatifard, Navdeep S Chandel, Issam Ben-Sahra
Pyrimidines maintain mitochondrial pyruvate oxidation to support de novo lipogenesis. Science (New York, N.Y.) 383 (6690) (2024)
J Contenti, Y Guo, M Larcher, L Mirabal-Ortega, M Rouleau, M Irondelle, V Tiroille, A Mazzu, V Duranton-Tanneur, F Pedeutour, Issam Ben-Sahra, C Lago, G Leva, Luca Tiberi, G Robert, C Pouponnot, F Bost, Nathalie M Mazure
HIF-1 inactivation empowers HIF-2 to drive hypoxia adaptation in aggressive forms of medulloblastoma. Cell death discovery 10 (1) (2024)
Umakant Sahu, Elodie Villa, Colleen R Reczek, Zibo Zhao, Brendan P O'Hara, Michael D Torno, Rohan Mishra, William D Shannon, John M Asara, Peng Gao, Ali Shilatifard, Navdeep S Chandel, Issam Ben-Sahra
Pyrimidines maintain mitochondrial pyruvate oxidation to support de novo lipogenesis. Science (New York, N.Y.) 383 (6690) (2024)
J Contenti, Y Guo, M Larcher, L Mirabal-Ortega, M Rouleau, M Irondelle, V Tiroille, A Mazzu, V Duranton-Tanneur, F Pedeutour, Issam Ben-Sahra, C Lago, G Leva, Luca Tiberi, G Robert, C Pouponnot, F Bost, Nathalie M Mazure
HIF-1 inactivation empowers HIF-2 to drive hypoxia adaptation in aggressive forms of medulloblastoma. Cell death discovery 10 (1) (2024)
J Contenti, Y Guo, M Larcher, L Mirabal-Ortega, M Rouleau, M Irondelle, V Tiroille, A Mazzu, V Duranton-Tanneur, F Pedeutour, Issam Ben-Sahra, C Lago, G Leva, Luca Tiberi, G Robert, C Pouponnot, F Bost, Nathalie M Mazure
HIF-1 inactivation empowers HIF-2 to drive hypoxia adaptation in aggressive forms of medulloblastoma. Cell death discovery 10 (1) (2024)
Umakant Sahu, Elodie Villa, Colleen R Reczek, Zibo Zhao, Brendan P O'Hara, Michael D Torno, Rohan Mishra, William D Shannon, John M Asara, Peng Gao, Ali Shilatifard, Navdeep S Chandel, Issam Ben-Sahra
Pyrimidines maintain mitochondrial pyruvate oxidation to support de novo lipogenesis. Science (New York, N.Y.) 383 (6690) (2024)
Umakant Sahu, Elodie Villa, Colleen R Reczek, Zibo Zhao, Brendan P O'Hara, Michael D Torno, Rohan Mishra, William D Shannon, John M Asara, Peng Gao, Ali Shilatifard, Navdeep S Chandel, Issam Ben-Sahra
Pyrimidines maintain mitochondrial pyruvate oxidation to support de novo lipogenesis. Science (New York, N.Y.) 383 (6690) (2024)
Umakant Sahu, Elodie Villa, Colleen R Reczek, Zibo Zhao, Brendan P O'Hara, Michael D Torno, Rohan Mishra, William D Shannon, John M Asara, Peng Gao, Ali Shilatifard, Navdeep S Chandel, Issam Ben-Sahra
Pyrimidines maintain mitochondrial pyruvate oxidation to support de novo lipogenesis. Science (New York, N.Y.) 383 (6690) (2024)
Umakant Sahu, Issam Ben-Sahra
The cell cycle loops UTP around CAD. Nature metabolism 5 (2) (2023)
Umakant Sahu, Issam Ben-Sahra
The cell cycle loops UTP around CAD. Nature metabolism (2023)
Jason S Shapiro, Hsiang-Chun Chang, Yuki Tatekoshi, Zibo Zhao, Zohra Sattar Waxali, Bong Jin Hong, Haimei Chen, Justin A Geier, Elizabeth Thomas Bartom, Adam De Jesus, Farnaz K Nejad, Amir Mahmoodzadeh, Tatsuya Sato, Lucia Ramos-Alonso, Antonia Maria Romero, Maria Teresa Martinez-Pastor, Shang-Chuan Jiang, Shiv K Sah-Teli, Liming Li, David Bentrem, Gary Lopaschuk, Issam Ben-Sahra, Thomas V O'Halloran, Ali Shilatifard, Sergi Puig, Joy Bergelson, Peppi Koivunen, Hossein Ardehali
Iron drives anabolic metabolism through active histone demethylation and mTORC1. Nature cell biology (2023)
Umakant Sahu, Issam Ben-Sahra
The cell cycle loops UTP around CAD. Nature metabolism 5 (2) (2023)
Kathryn M Lemberg, Eunus S Ali, Marcela Krecmerova, Joanna Marie H Aguilar, Jesse Alt, Diane E Peters, Liang Zhao, Ying Wu, Naziba Nuha, John M Asara, Verena Staedtke, Christine A Pratilas, Pavel Majer, Rana Rais, Issam Ben-Sahra, Barbara S Slusher
Pro-905, a novel purine antimetabolite, combines with glutamine amidotransferase inhibition to suppress growth of malignant peripheral nerve sheath tumor. Molecular cancer therapeutics (2023)
Qian Ma, Qiuhua Yang, Jiean Xu, Hunter G Sellers, Zach L Brown, Zhiping Liu, Zsuzsanna Bordan, Xiaofan Shi, Dingwei Zhao, Yongfeng Cai, Vidhi Pareek, Chunxiang Zhang, Guangyu Wu, Zheng Dong, Alexander D Verin, Lin Gan, Quansheng Du, Stephen J Benkovic, Jianping Weng, John M Asara, Issam Ben-Sahra, Scott Barman, Yunchao Su, David J R Fulton, Yuqing Huo
Purine synthesis suppression reduces the development and progression of pulmonary hypertension in rodent models. European heart journal (2023)
Qian Ma, Qiuhua Yang, Jiean Xu, Hunter G Sellers, Zach L Brown, Zhiping Liu, Zsuzsanna Bordan, Xiaofan Shi, Dingwei Zhao, Yongfeng Cai, Vidhi Pareek, Chunxiang Zhang, Guangyu Wu, Zheng Dong, Alexander D Verin, Lin Gan, Quansheng Du, Stephen J Benkovic, Jianping Weng, John M Asara, Issam Ben-Sahra, Scott Barman, Yunchao Su, David J R Fulton, Yuqing Huo
Purine synthesis suppression reduces the development and progression of pulmonary hypertension in rodent models. European heart journal (2023)
Ella N Perrault, Jack M Shireman, Eunus S Ali, Peiyu Lin, Isabelle Preddy, Cheol Park, Shreya Budhiraja, Shivani Baisiwala, Karan S Dixit, C David James, Dieter H Heiland, Issam Ben-Sahra, Sebastian Pott, Anindita Basu, Jason M Miska, Atique U Ahmed
Ribonucleotide reductase regulatory subunit M2 drives glioblastoma TMZ resistance through modulation of dNTP production. Science advances 9 (20) (2023)
Ella N Perrault, Jack M Shireman, Eunus S Ali, Peiyu Lin, Isabelle Preddy, Cheol Park, Shreya Budhiraja, Shivani Baisiwala, Karan S Dixit, C David James, Dieter H Heiland, Issam Ben-Sahra, Sebastian Pott, Anindita Basu, Jason M Miska, Atique U Ahmed
Ribonucleotide reductase regulatory subunit M2 drives glioblastoma TMZ resistance through modulation of dNTP production. Science advances 9 (20) (2023)
Ella N Perrault, Jack M Shireman, Eunus S Ali, Peiyu Lin, Isabelle Preddy, Cheol Park, Shreya Budhiraja, Shivani Baisiwala, Karan S Dixit, C David James, Dieter H Heiland, Issam Ben-Sahra, Sebastian Pott, Anindita Basu, Jason M Miska, Atique U Ahmed
Ribonucleotide reductase regulatory subunit M2 drives glioblastoma TMZ resistance through modulation of dNTP production. Science advances 9 (20) (2023)
J Contenti, Y Guo, M Larcher, L Mirabal-Ortega, M Rouleau, M Irondelle, V Tiroille, A Mazzu, V Duranton-Tanneur, F Pedeutour, Issam Ben-Sahra, Chiara Lago, Gloria Leva, Luca Tiberi, G Robert, Célio Pouponnot, F Bost, Nathalie M Mazure
HIF-1 inactivation empowers HIF-2 to drive hypoxia adaptation in aggressive forms of medulloblastoma. bioRxiv : the preprint server for biology (2023)
Elodie Villa, Issam Ben-Sahra
ASS1igning purine dependency to cancer. Nature cancer 1 (9) (2022)
Jeffrey D Calhoun, Miriam C Aziz, Hannah C Happ, Jonathan Gunti, Colleen Gleason, Najma Mohamed, Kristy Zeng, Meredith Hiller, Emily Bryant, Divakar S Mithal, Irena Bellinski, Lisa Kinsley, Mona Grimmel, Eva M C Schwaibold, Constance Smith-Hicks, Anna Chassevent, Marcello Scala, Andrea Accogli, Annalaura Torella, Pasquale Striano, Valeria Capra, Lynne M Bird, Issam Ben-Sahra, Nina Ekhilevich, Tova Hershkovitz, Karin Weiss, John Millichap, Elizabeth E Gerard, Gemma Louise Carvill
mTORC1 functional assay reveals SZT2 loss-of-function variants and a founder in-frame deletion. Brain : a journal of neurology 145 (6) (2022)
Qi Jin, Blanca T Gutierrez-Diaz, Tim Pieters, Yalu Zhou, Sonali Narang, Igor Fijalkwoski, Cristina Borin, Jolien Van Laere, Monique Payton, Byoung-Kyu Cho, Cuijuan Han, Limin Sun, Valentina Serafin, George Yacu, Wouter Van Loocke, Giuseppe Basso, Giulia Veltri, Ingrid Dreveny, Issam Ben-Sahra, Young Ah Goo, Stephanie L Safgren, Yi-Chien Tsai, Beat C Bornhauser, Praveen Kumar Suraneni, Alexandre Gaspar-Maia, Irawati Kandela, Pieter Van Vlierberghe, John D Crispino, Aristotelis Tsirigos, Panagiotis Ntziachristos
Oncogenic deubiquitination controls tyrosine kinase signaling and therapy response in acute lymphoblastic leukemia. Science advances 8 (49) (2022)
Qi Jin, Blanca T Gutierrez-Diaz, Tim Pieters, Yalu Zhou, Sonali Narang, Igor Fijalkwoski, Cristina Borin, Jolien Van Laere, Monique Payton, Byoung-Kyu Cho, Cuijuan Han, Limin Sun, Valentina Serafin, George Yacu, Wouter Van Loocke, Giuseppe Basso, Giulia Veltri, Ingrid Dreveny, Issam Ben-Sahra, Young Ah Goo, Stephanie L Safgren, Yi-Chien Tsai, Beat C Bornhauser, Praveen Kumar Suraneni, Alexandre Gaspar-Maia, Irawati Kandela, Pieter Van Vlierberghe, John D Crispino, Aristotelis Tsirigos, Panagiotis Ntziachristos
Oncogenic deubiquitination controls tyrosine kinase signaling and therapy response in acute lymphoblastic leukemia. Science advances 8 (49) (2022)
Qi Jin, Blanca T Gutierrez-Diaz, Tim Pieters, Yalu Zhou, Sonali Narang, Igor Fijalkwoski, Cristina Borin, Jolien Van Laere, Monique Payton, Byoung-Kyu Cho, Cuijuan Han, Limin Sun, Valentina Serafin, George Yacu, Wouter Van Loocke, Giuseppe Basso, Giulia Veltri, Ingrid Dreveny, Issam Ben-Sahra, Young Ah Goo, Stephanie L Safgren, Yi-Chien Tsai, Beat C Bornhauser, Praveen Kumar Suraneni, Alexandre Gaspar-Maia, Irawati Kandela, Pieter Van Vlierberghe, John D Crispino, Aristotelis Tsirigos, Panagiotis Ntziachristos
Oncogenic deubiquitination controls tyrosine kinase signaling and therapy response in acute lymphoblastic leukemia. Science advances 8 (49) (2022)
Mona Hoseini Soflaee, Rushendhiran Kesavan, Umakant Sahu, Alpaslan Tasdogan, Elodie Villa, Zied Djabari, Feng Cai, Tran Hong Diem, Hieu S Vu, Eunus S Ali, Halie Rion, Brendan P O'Hara, Sherwin Kelekar, James Hughes Hallett, Misty Martin, Thomas P Mathews, Peng Gao, John M Asara, Brendan D Manning, Issam Ben-Sahra, Gerta Hoxhaj
Purine nucleotide depletion prompts cell migration by stimulating the serine synthesis pathway. Nature communications 13 (1) (2022)
Qi Jin, Blanca T Gutierrez-Diaz, Tim Pieters, Yalu Zhou, Sonali Narang, Igor Fijalkwoski, Cristina Borin, Jolien Van Laere, Monique Payton, Byoung-Kyu Cho, Cuijuan Han, Limin Sun, Valentina Serafin, George Yacu, Wouter Van Loocke, Giuseppe Basso, Giulia Veltri, Ingrid Dreveny, Issam Ben-Sahra, Young Ah Goo, Stephanie L Safgren, Yi-Chien Tsai, Beat C Bornhauser, Praveen Kumar Suraneni, Alexandre Gaspar-Maia, Irawati Kandela, Pieter Van Vlierberghe, John D Crispino, Aristotelis Tsirigos, Panagiotis Ntziachristos
Oncogenic deubiquitination controls tyrosine kinase signaling and therapy response in acute lymphoblastic leukemia. Science advances 8 (49) (2022)
David R Amici, Daniel J Ansel, Kyle A Metz, Roger S Smith, Claire M Phoumyvong, Sitaram Gayatri, Tomasz Chamera, Stacey L Edwards, Brendan P O'Hara, Shashank Srivastava, Sonia Brockway, Seesha R Takagishi, Byoung-Kyu Cho, Young Ah Goo, Michael P Snyder, Issam Ben-Sahra, Daniel R Foltz, Jian Li, Marc L Mendillo
C16orf72/HAPSTR1 is a molecular rheostat in an integrated network of stress response pathways. Proceedings of the National Academy of Sciences of the United States of America 119 (27) (2022)
Qi Jin, Blanca T Gutierrez-Diaz, Tim Pieters, Yalu Zhou, Sonali Narang, Igor Fijalkwoski, Cristina Borin, Jolien Van Laere, Monique Payton, Byoung-Kyu Cho, Cuijuan Han, Limin Sun, Valentina Serafin, George Yacu, Wouter Van Loocke, Giuseppe Basso, Giulia Veltri, Ingrid Dreveny, Issam Ben-Sahra, Young Ah Goo, Stephanie L Safgren, Yi-Chien Tsai, Beat C Bornhauser, Praveen Kumar Suraneni, Alexandre Gaspar-Maia, Irawati Kandela, Pieter Van Vlierberghe, John D Crispino, Aristotelis Tsirigos, Panagiotis Ntziachristos
Oncogenic deubiquitination controls tyrosine kinase signaling and therapy response in acute lymphoblastic leukemia. Science advances 8 (49) (2022)
Qi Jin, Blanca T Gutierrez-Diaz, Tim Pieters, Yalu Zhou, Sonali Narang, Igor Fijalkwoski, Cristina Borin, Jolien Van Laere, Monique Payton, Byoung-Kyu Cho, Cuijuan Han, Limin Sun, Valentina Serafin, George Yacu, Wouter Van Loocke, Giuseppe Basso, Giulia Veltri, Ingrid Dreveny, Issam Ben-Sahra, Young Ah Goo, Stephanie L Safgren, Yi-Chien Tsai, Beat C Bornhauser, Praveen Kumar Suraneni, Alexandre Gaspar-Maia, Irawati Kandela, Pieter Van Vlierberghe, John D Crispino, Aristotelis Tsirigos, Panagiotis Ntziachristos
Oncogenic deubiquitination controls tyrosine kinase signaling and therapy response in acute lymphoblastic leukemia. Science advances 8 (49) (2022)
Qi Jin, Blanca T Gutierrez-Diaz, Tim Pieters, Yalu Zhou, Sonali Narang, Igor Fijalkwoski, Cristina Borin, Jolien Van Laere, Monique Payton, Byoung-Kyu Cho, Cuijuan Han, Limin Sun, Valentina Serafin, George Yacu, Wouter Van Loocke, Giuseppe Basso, Giulia Veltri, Ingrid Dreveny, Issam Ben-Sahra, Young Ah Goo, Stephanie L Safgren, Yi-Chien Tsai, Beat C Bornhauser, Praveen Kumar Suraneni, Alexandre Gaspar-Maia, Irawati Kandela, Pieter Van Vlierberghe, John D Crispino, Aristotelis Tsirigos, Panagiotis Ntziachristos
Oncogenic deubiquitination controls tyrosine kinase signaling and therapy response in acute lymphoblastic leukemia. Science advances 8 (49) (2022)
Qi Jin, Blanca T Gutierrez-Diaz, Tim Pieters, Yalu Zhou, Sonali Narang, Igor Fijalkwoski, Cristina Borin, Jolien Van Laere, Monique Payton, Byoung-Kyu Cho, Cuijuan Han, Limin Sun, Valentina Serafin, George Yacu, Wouter Van Loocke, Giuseppe Basso, Giulia Veltri, Ingrid Dreveny, Issam Ben-Sahra, Young Ah Goo, Stephanie L Safgren, Yi-Chien Tsai, Beat C Bornhauser, Praveen Kumar Suraneni, Alexandre Gaspar-Maia, Irawati Kandela, Pieter Van Vlierberghe, John D Crispino, Aristotelis Tsirigos, Panagiotis Ntziachristos
Oncogenic deubiquitination controls tyrosine kinase signaling and therapy response in acute lymphoblastic leukemia. Science advances 8 (49) (2022)
Qian Ma, Qiuhua Yang, Jiean Xu, Xiaoyu Zhang, David S Kim, Zhiping Liu, Qingen Da, Xiaoxiao Mao, Yaqi Zhou, Yongfeng Cai, Vidhi Pareek, Ha Won Kim, Guangyu Wu, Zheng Dong, Wen-Liang Song, Lin Gan, Chun-Xiang Zhang, Mei Hong, Stephen J Benkovic, Neal L Weintraub, David J R Fulton, John M Asara, Issam Ben-Sahra, Yuqing Huo
ATIC-Associated De Novo Purine Synthesis Is Critically Involved in Proliferative Arterial Disease. Circulation 146 (19) (2022)
Jack M Shireman, Fatemeh Atashi, Gina Lee, Eunus S Ali, Miranda R Saathoff, Cheol H Park, Sol Savchuk, Shivani Baisiwala, Jason Miska, Maciej S Lesniak, C David James, Roger Stupp, Priya U Kumthekar, Craig M Horbinski, Issam Ben-Sahra, Atique U Ahmed
De novo purine biosynthesis is a major driver of chemoresistance in glioblastoma. Brain : a journal of neurology 144 (4) (2021)
Anthony J Covarrubias, Abhijit Kale, Rosalba Perrone, José Alberto López-Domínguez, Angela Oliveira Pisco, Herbert G Kasler, Mark S Schmidt, Indra Heckenbach, Ryan Kwok, Christopher D Wiley, Hoi-Shan Wong, Eddy Gibbs, Shankar S Iyer, Nathan Basisty, Qiuxia Wu, Ik-Jung Kim, Elena Silva, Kaitlyn Vitangcol, Kyong-Oh Shin, Yong-Moon Lee, Rebeccah Riley, Issam Ben-Sahra, Melanie Ott, Birgit Schilling, Morten Scheibye-Knudsen, Katsuhiko Ishihara, Stephen R Quake, John C Newman, Charles Brenner, Judith Campisi, Eric Verdin
Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages. Nature metabolism 2 (11) (2020)
Anthony J Covarrubias, Abhijit Kale, Rosalba Perrone, José Alberto López-Domínguez, Angela Oliveira Pisco, Herbert G Kasler, Mark S Schmidt, Indra Heckenbach, Ryan Kwok, Christopher D Wiley, Hoi-Shan Wong, Eddy Gibbs, Shankar S Iyer, Nathan Basisty, Qiuxia Wu, Ik-Jung Kim, Elena Silva, Kaitlyn Vitangcol, Kyong-Oh Shin, Yong-Moon Lee, Rebeccah Riley, Issam Ben-Sahra, Melanie Ott, Birgit Schilling, Morten Scheibye-Knudsen, Katsuhiko Ishihara, Stephen R Quake, John C Newman, Charles Brenner, Judith Campisi, Eric Verdin
Author Correction: Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages. Nature metabolism (2020)
Elodie Villa, Eunus S Ali, Umakant Sahu, Issam Ben-Sahra
Cancer Cells Tune the Signaling Pathways to Empower de Novo Synthesis of Nucleotides. Cancers 11 (5) (2019)

Issam Ben-Sahra.css-eqlu8i{font-size:small;padding-left:4px;} (I Ben-Sahra)

Publication Activity (10 Years)

Top Topics

Top Venues

Issam Ben-Sahra (I Ben-Sahra)