Gut microbiota composition during a 12-week intervention with delayed-release dimethyl fumarate in multiple sclerosis - a pilot trial.

C Storm-LarsenK-M MyhrE FarbuR MidgardK NyquistL BrochP Berg-HansenA BunessK HolmT UelandL-E FallangE Burum-AuensenJohannes Roksund HovT Holmøy

Published in: Multiple sclerosis journal - experimental, translational and clinical (2019)

This pilot study did not detect a major effect of dimethyl fumarate on the gut microbiota composition, but we observed a trend towards normalization of the low abundance of butyrate-producing Faecalibacterium after 12 weeks treatment. The study was underpowered to link microbiota to gastrointestinal symptoms.

Keyphrases

multiple sclerosis
randomized controlled trial
clinical trial
combination therapy
white matter
sleep quality
physical activity
smoking cessation