Combination of EGFR-Directed Tyrosine Kinase Inhibitors (EGFR-TKI) with Radiotherapy in Brain Metastases from Non-Small Cell Lung Cancer: A 2010-2019 Retrospective Cohort Study.
Vineeth TatineniPatrick J O'SheaShreya SaxenaAtulya Aman KhoslaAhmad OzairRupesh R KotechaXuefei JiaYasmeen RaufErin S MurphySamuel T ChaoJohn H SuhDavid M PeereboomManmeet S AhluwaliaPublished in: Cancers (2023)
NSCLCBM patients treated with SRS had a significantly higher OS compared to patients treated with WBRT-only. While sample-size limitations and investigator-associated selection bias may limit the generalizability of these results, phase II/III clinicals trials are warranted to investigate synergistic efficacy of EGFR-TKI and SRS.