Removal of the infrapatellar fat pad and associated synovium benefits female guinea pigs in the Dunkin Hartley model of idiopathic osteoarthritis.
Maryam F AfzaliMadeline M SykesLindsey H BurtonKayley M PattonKoryn R LeeCassie SeebartNicole VigonRyan EkGerardo E NarezAngela J MarolfKatie J SikesTammy L Haut DonahueKelly S SantangeloPublished in: Annals of translational medicine (2024)
Our data suggest that the IFP/SC is a significant component driving knee OA in female guinea pigs and that resection of this tissue prior to disease has short-term benefits. Specifically, the formation of the FCT in place of the native tissue resulted in decreased cartilage-related OA changes, as demonstrated by reduced Osteoarthritis Research Society International (OARSI) histology scores, as well as changes in transcript, protein, and cartilage indentation analyses. Importantly, this model provides evidence that sex needs to be considered when investigating responses and associated mechanisms seen with this intervention.
Keyphrases
- knee osteoarthritis
- rheumatoid arthritis
- randomized controlled trial
- extracellular matrix
- total knee arthroplasty
- adipose tissue
- electronic health record
- rna seq
- protein protein
- high resolution
- big data
- small molecule
- atomic force microscopy
- deep learning
- artificial intelligence
- single molecule
- high speed
- anterior cruciate ligament