Subgroup-specific outcomes of children with malignant childhood brain tumors treated with an irradiation-sparing protocol.

Eveline Teresa HidalgoMatija SnuderlCordelia OrillacSvetlana KvintJonathan SerranoPeter WuMatthias A KarajannisSharon L Gardner

Published in: Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery (2019)

The efficacy of high-dose chemotherapy radiation-sparing treatment appears to be confined to favorable molecular subgroups of pediatric brain tumors, such as infant SHH MB. Identification of molecular subgroups that benefit from radiation-sparing therapy will aid in the design of prospective, "precision medicine"-driven clinical trials.

Keyphrases

robot assisted
high dose
clinical trial
radiation induced
young adults
randomized controlled trial
low dose
single molecule
phase iii
childhood cancer
squamous cell carcinoma
radiation therapy
minimally invasive
adipose tissue
early life
mesenchymal stem cells
open label
glycemic control