A possible mechanism underlying mood disorders associated with LUTS: Chronic bladder outlet obstruction causes NLRP3-dependent inflammation in the hippocampus and depressive behavior in rats.
Francis M HughesNathan A HirshmanHamza A MalickSimon W WhiteHuixia JinShelby N HarperJ Todd PurvesPublished in: Neurourology and urodynamics (2020)
BOO, a bladder-localized event, stimulates NLRP3-dependent inflammation in the rat hippocampus after 12 weeks and this inflammation causes depressive behavior. This is the first mechanistic explanation of the link between BOO and depression and provides evidence for a distinct bladder-brain axis.