Francis M Hughes

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 22

Top Venues

Science immunology

American journal of physiology. Renal physiology

International journal of molecular sciences

Neurourology and urodynamics

Clemson University

Medical University of South Carolina (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Clemson University Jan 01 2016

United States

Adjunct Associate Professor :: Bioengineering

Duke University Jun 01 2015

United States

Assistant Professor :: Surgery

Medical University of South Carolina

United States

Staff Scientist II :: Urology

Medical University of South Carolina

United States

Visiting Associate professor :: Pharmaceutical Sciences

Argolyn Biosciences

United States

Director, Biology Division

University of North Carolina at Charlotte

United States

Associate professor :: Biology

National Institute of Environmental Health Sciences

United States

IRTA Fellow :: Cell Signalling

University of North Carolina at Chapel Hill

United States

Postdoctoral Research Associate :: Physiology

Education History

Medical University of South Carolina Sep 01 1987

United States

PHD :: Cell Biology

Clemson University

United States

BSC :: Biochemistry

Publications

Anissa Cervantes, Francis M Hughes, Huixia Jin, J Todd Purves
Specialized pro-resolution mediators in the bladder: effects of resolvin E1 on diabetic bladder dysfunction in the type 1 diabetic male Akita mouse model. BMC urology 24 (1) (2024)
Francis M Hughes, Shelby N Harper, Huixia Jin, Michael R Odom, J Todd Purves
Strict glucose control and elimination of NLRP3-induced inflammation prevents diabetic bladder dysfunction in the female Akita mouse model. Neurourology and urodynamics (2024)
Byron W Hayes, Hae Woong Choi, Abhay P S Rathore, Chunjing Bao, Jianling Shi, Yul Huh, Michael W Kim, Qingfeng Chen, Pradeep Bist, Lai Guan Ng, Chang-Ming Shih, Joo Hwan Nho, Aram Kim, Hana Yoon, Donghoon Lim, Johanna L Hannan, J Todd Purves, Francis M Hughes, Ru-Rong Ji, Soman N Abraham
Recurrent infections drive persistent bladder dysfunction and pain via sensory nerve sprouting and mast cell activity. Science immunology 9 (93) (2024)
Anissa Cervantes, Francis M Hughes, Huixia Jin, J Todd Purves
Specialized pro-resolution mediators in the bladder: effects of resolvin E1 on diabetic bladder dysfunction in the type 1 diabetic male Akita mouse model. BMC urology 24 (1) (2024)
Byron W Hayes, Hae Woong Choi, Abhay P S Rathore, Chunjing Bao, Jianling Shi, Yul Huh, Michael W Kim, Qingfeng Chen, Pradeep Bist, Lai Guan Ng, Chang-Ming Shih, Joo Hwan Nho, Aram Kim, Hana Yoon, Donghoon Lim, Johanna L Hannan, J Todd Purves, Francis M Hughes, Ru-Rong Ji, Soman N Abraham
Recurrent infections drive persistent bladder dysfunction and pain via sensory nerve sprouting and mast cell activity. Science immunology 9 (93) (2024)
Byron W Hayes, Hae Woong Choi, Abhay P S Rathore, Chunjing Bao, Jianling Shi, Yul Huh, Michael W Kim, Qingfeng Chen, Pradeep Bist, Lai Guan Ng, Chang-Ming Shih, Joo Hwan Nho, Aram Kim, Hana Yoon, Donghoon Lim, Johanna L Hannan, J Todd Purves, Francis M Hughes, Ru-Rong Ji, Soman N Abraham
Recurrent infections drive persistent bladder dysfunction and pain via sensory nerve sprouting and mast cell activity. Science immunology 9 (93) (2024)
Byron W Hayes, Hae Woong Choi, Abhay P S Rathore, Chunjing Bao, Jianling Shi, Yul Huh, Michael W Kim, Qingfeng Chen, Pradeep Bist, Lai Guan Ng, Chang-Ming Shih, Joo Hwan Nho, Aram Kim, Hana Yoon, Donghoon Lim, Johanna L Hannan, J Todd Purves, Francis M Hughes, Ru-Rong Ji, Soman N Abraham
Recurrent infections drive persistent bladder dysfunction and pain via sensory nerve sprouting and mast cell activity. Science immunology 9 (93) (2024)
Byron W Hayes, Hae Woong Choi, Abhay P S Rathore, Chunjing Bao, Jianling Shi, Yul Huh, Michael W Kim, Qingfeng Chen, Pradeep Bist, Lai Guan Ng, Chang-Ming Shih, Joo Hwan Nho, Aram Kim, Hana Yoon, Donghoon Lim, Johanna L Hannan, J Todd Purves, Francis M Hughes, Ru-Rong Ji, Soman N Abraham
Recurrent infections drive persistent bladder dysfunction and pain via sensory nerve sprouting and mast cell activity. Science immunology 9 (93) (2024)
Byron W Hayes, Hae Woong Choi, Abhay P S Rathore, Chunjing Bao, Jianling Shi, Yul Huh, Michael W Kim, Qingfeng Chen, Pradeep Bist, Lai Guan Ng, Chang-Ming Shih, Joo Hwan Nho, Aram Kim, Hana Yoon, Donghoon Lim, Johanna L Hannan, J Todd Purves, Francis M Hughes, Ru-Rong Ji, Soman N Abraham
Recurrent infections drive persistent bladder dysfunction and pain via sensory nerve sprouting and mast cell activity. Science immunology 9 (93) (2024)
Francis M Hughes, Michael R Odom, Anissa Cervantes, Austin J Livingston, J Todd Purves
Why Are Some People with Lower Urinary Tract Symptoms (LUTS) Depressed? New Evidence That Peripheral Inflammation in the Bladder Causes Central Inflammation and Mood Disorders. International journal of molecular sciences 24 (3) (2023)
Francis M Hughes, Michael R Odom, Anissa Cervantes, Austin J Livingston, J Todd Purves
Why Are Some People with Lower Urinary Tract Symptoms (LUTS) Depressed? New Evidence That Peripheral Inflammation in the Bladder Causes Central Inflammation and Mood Disorders. International journal of molecular sciences 24 (3) (2023)
Francis M Hughes, Michael R Odom, Anissa Cervantes, Austin J Livingston, J Todd Purves
Why Are Some People with Lower Urinary Tract Symptoms (LUTS) Depressed? New Evidence That Peripheral Inflammation in the Bladder Causes Central Inflammation and Mood Disorders. International journal of molecular sciences 24 (3) (2023)
Francis M Hughes, Armand Allkanjari, Michael R Odom, Huixia Jin, J Todd Purves
Specialized pro-resolution mediators in the bladder: Receptor expression and recovery of bladder function from cystitis. Experimental biology and medicine (Maywood, N.J.) 247 (8) (2022)
Michael R Odom, Francis M Hughes, Huixia Jin, J Todd Purves
Diabetes causes NLRP3-dependent barrier dysfunction in mice with detrusor overactivity but not underactivity. American journal of physiology. Renal physiology 323 (6) (2022)
Francis M Hughes, Shelby N Harper, Brent D Nosé, Armand Allkanjari, Michael T Zheng, Huixia Jin, J Todd Purves
Specialized proresolution mediators in the bladder: annexin-A1 normalizes inflammation and bladder dysfunction during bladder outlet obstruction. American journal of physiology. Renal physiology 321 (4) (2021)
Francis M Hughes, Nathan A Hirshman, Hamza A Malick, Simon W White, Huixia Jin, Shelby N Harper, J Todd Purves
A possible mechanism underlying mood disorders associated with LUTS: Chronic bladder outlet obstruction causes NLRP3-dependent inflammation in the hippocampus and depressive behavior in rats. Neurourology and urodynamics 39 (6) (2020)
Shelby N Harper, Patrick D Leidig, Francis M Hughes, Huixia Jin, J Todd Purves
Calcium Pyrophosphate And Monosodium Urate Activate The NLRP3 Inflammasome Within Bladder Urothelium Via Reactive Oxygen Species And TXNIP. Research and reports in urology 11 (2019)
Nathan A Hirshman, Francis M Hughes, Huixia Jin, William T Harrison, Simon W White, Isabelle Doan, Shelby N Harper, Patrick D Leidig, J Todd Purves
Cyclophosphamide-induced cystitis results in NLRP3-mediated inflammation in the hippocampus and symptoms of depression in rats. American journal of physiology. Renal physiology 318 (2) (2019)
Francis M Hughes, Nathan A Hirshman, Brian M Inouye, Huixia Jin, Eloise W Stanton, Chloe E Yun, Leah G Davis, Jonathan C Routh, J Todd Purves
NLRP3 Promotes Diabetic Bladder Dysfunction and Changes in Symptom-Specific Bladder Innervation. Diabetes 68 (2) (2018)
Francis M Hughes, Stephanie J Sexton, Patrick D Ledig, Chloe E Yun, Huixia Jin, J Todd Purves
Bladder decompensation and reduction in nerve density in a rat model of chronic bladder outlet obstruction are attenuated with the NLRP3 inhibitor glyburide. American journal of physiology. Renal physiology 316 (1) (2018)
Robin Lütolf, Francis M Hughes, Brian M Inouye, Huixia Jin, Jennifer C McMains, Elena S Pak, Johanna L Hannan, J Todd Purves
NLRP3/IL-1β mediates denervation during bladder outlet obstruction in rats. Neurourology and urodynamics 37 (3) (2017)
Francis M Hughes, Stephanie J Sexton, Huixia Jin, Vihasa Govada, J Todd Purves
Bladder fibrosis during outlet obstruction is triggered through the NLRP3 inflammasome and the production of IL-1β. American journal of physiology. Renal physiology 313 (3) (2017)

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Publication Activity (10 Years)

Top Topics

Top Venues

Francis M Hughes