Effects of 6,8-Diprenylgenistein on VEGF-A-Induced Lymphangiogenesis and Lymph Node Metastasis in an Oral Cancer Sentinel Lymph Node Animal Model.
Mun Gyeong BaeJeon Hwang-BoDae Young LeeYoun-Hyung LeeIn Sik ChungPublished in: International journal of molecular sciences (2021)
These data suggest that 6,8-DG inhibits VEGF-A-induced lymphangiogenesis and lymph node metastasis in vitro and in vivo. Furthermore, the inhibitory effects of 6,8-DG are probably mediated by inhibition of VEGF-A expression in cancer cells and suppression of the VEGF-A/VEGFR-2 signaling pathway in HLMEC. Thus, 6,8-DG could be novel and valuable therapeutic agents for metastasis prevention and treatment of oral cancer.
Keyphrases
- lymph node metastasis
- vascular endothelial growth factor
- endothelial cells
- high glucose
- sentinel lymph node
- squamous cell carcinoma
- papillary thyroid
- signaling pathway
- diabetic rats
- lymph node
- early stage
- poor prognosis
- epithelial mesenchymal transition
- machine learning
- pi k akt
- electronic health record
- radiation therapy
- rectal cancer
- binding protein