Login / Signup

Tolerability profile of topical cannabidiol and palmitoylethanolamide: a compilation of single-centre randomized evaluator-blinded clinical and in vitro studies in normal skin.

Jalal MaghfourH RietcheckM D SzetoChandler W RundleT E SivesindRobert Paul DellavalleP LioC A DunnickJ FernandezH Yardley
Published in: Clinical and experimental dermatology (2021)
These specific formulations of CBD- and PEA-containing products are nonirritating and nonsensitizing in healthy adults, and further encourage similar research assessing their long-term safety and efficacy in human participants with dermatological diseases. There are some limitations to the study: (i) external validity may be limited as formulations from a single manufacturer were used for this study, while vast heterogeneity exists across unregulated, commercial CBD products on the market; and (ii) products were assessed only on normal, nondiseased human skin, and therefore extrapolation to those with dermatological diseases cannot be assumed.
Keyphrases
  • placebo controlled
  • open label
  • double blind
  • endothelial cells
  • randomized controlled trial
  • clinical trial
  • wound healing
  • health insurance
  • phase ii