Methylation of protein aspartates and deamidated asparagines as a function of blood bank storage and oxidative stress in human red blood cells.
Julie A ReiszTravis NemkovMonika DzieciatkowskaRachel Culp-HillDavide StefanoniRyan C HillTatsuro YoshidaAndrew DunhamTamir KaniasLarry J DumontMichael BuschElan Z EisenmesserJames C ZimringKirk C HansenAngelo D'AlessandroPublished in: Transfusion (2018)
While methylation of basic amino acid residues serves as an epigenetic modification in nucleated cells, protein methylation at carboxylate side chains and deamidated asparagines is a nonepigenetic posttranslational sensor of oxidative stress and refrigerated storage in anucleated human RBCs.
Keyphrases
- oxidative stress
- amino acid
- induced apoptosis
- dna methylation
- endothelial cells
- genome wide
- red blood cell
- induced pluripotent stem cells
- dna damage
- gene expression
- pluripotent stem cells
- ischemia reperfusion injury
- endoplasmic reticulum stress
- cell cycle arrest
- cell proliferation
- binding protein
- cord blood
- heat shock
- heat shock protein