Krill oil extract inhibits the migration of human colorectal cancer cells and down-regulates EGFR signalling and PD-L1 expression.

Abilasha G JayathilakeMargaret F VealeRodney Brain LuworKulmira NurgaliXiao Qun Su

Published in: BMC complementary medicine and therapies (2020)

This study has demonstrated that krill oil may be a potential therapeutic/adjunctive agent for CRC attributed to its anti-migratory effects.. The potential anti-cancer properties of krill oil are likely to be associated with the downregulation of EGFR, pEGFR and their downstream pERK/ERK1/2 and pAKT/AKT signalling pathways along with the downregulation of PD-L1.

Keyphrases

signaling pathway
cell proliferation
small cell lung cancer
epidermal growth factor receptor
tyrosine kinase
fatty acid
endothelial cells
pi k akt
oxidative stress
induced pluripotent stem cells
risk assessment
anti inflammatory
human health