Targeted multiomics in childhood-onset SLE reveal distinct biological phenotypes associated with disease activity: results from an explorative study.
Mohamed Javad WahadatSander J van TilburgYvonne M MuellerHarm de WitCornelia G Van Helden-MeeuwsenAnton W LangerakMarike J GruijtersAmani MubarakMarleen VerkaaikPeter D KatsikisMarjan A VersnelSylvia KamphuisPublished in: Lupus science & medicine (2023)
Using a targeted multiomic approach, we clustered patients into distinct biological phenotypes that are related to disease activity state but not to organ system involvement. This supports a new concept where choice of treatment and tapering strategies are not solely based on clinical phenotype but includes measuring novel biological parameters.
Keyphrases
- disease activity
- systemic lupus erythematosus
- rheumatoid arthritis
- rheumatoid arthritis patients
- ankylosing spondylitis
- juvenile idiopathic arthritis
- end stage renal disease
- chronic kidney disease
- newly diagnosed
- ejection fraction
- cancer therapy
- peritoneal dialysis
- prognostic factors
- single cell
- patient reported outcomes
- drug delivery
- replacement therapy
- decision making