PML-II regulates ERK and AKT signal activation and IFNα-induced cell death.

Xueqiong MengYixiang ChenSalvador MacipKeith N Leppard

Published in: Cell communication and signaling : CCS (2021)

The positive contribution of PML-II to the expression of various IFNα-induced pro-apoptotic proteins and its inhibition of pro-survival signaling together provide a mechanistic explanation for reduced apoptosis under conditions of PML deficiency and may account for at least part of the role of PML as a tumor suppressor gene. Video Abstract.

Keyphrases

cell death
high glucose
cell cycle arrest
diabetic rats
signaling pathway
cell proliferation
anti inflammatory
immune response
dendritic cells
oxidative stress
poor prognosis
drug induced
endoplasmic reticulum stress
gene expression
endothelial cells
binding protein
long non coding rna
dna methylation
stress induced