Expression of Otx Genes in Müller Cells Using an In Vitro Experimental Model of Retinal Hypoxia.
Claudio AzzoliniSimone DonatiGiovanni MicheloniVittoria MorettiRoberto ValliFrancesco AcquatiLucy CostantinoFulvio FerraraDavide BorroniElias PremiFrancesco TestaFrancesca SimonelliGiovanni PortaPublished in: Journal of ophthalmology (2021)
. Our molecular analysis is able to describe the activation of a set of genes, never before described, that can drive the response to a hypoxia-like status. The improved comprehension of these cellular events will be useful for designing new therapeutical approaches for retinal pathologies.
Keyphrases
- optical coherence tomography
- diabetic retinopathy
- genome wide
- induced apoptosis
- endothelial cells
- poor prognosis
- genome wide identification
- bioinformatics analysis
- optic nerve
- cell cycle arrest
- genome wide analysis
- endoplasmic reticulum stress
- dna methylation
- gene expression
- signaling pathway
- binding protein
- cell death
- transcription factor