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Silver-Mediated Direct C-H Cyanation of Terminal Alkynes with N-Isocyanoiminotriphenylphosphorane.

Hannan WangPengbing MiWanjun ZhaoRavi KumarXihe Bi
Published in: Organic letters (2017)
A direct cyanation of terminal alkynes for the synthesis of propionitrile derivatives, with the aid of silver salt using water additive, has been achieved. The cyano source used is N-isocyanoiminotriphenylphosphorane, which is nontoxic, safe, and easy to handle. This protocol is characterized by its operational simplicity, high efficiency with excellent yields, broad substrate scope, and greater functional group tolerance.
Keyphrases
  • high efficiency
  • gold nanoparticles
  • silver nanoparticles
  • randomized controlled trial