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Changes in T-cell subsets and clonal repertoire during chemoimmunotherapy with pembrolizumab and paclitaxel or capecitabine for metastatic triple-negative breast cancer.

Brie ChunJoanna PucilowskaShuChing ChangIsaac KimBenjamin NikitinYoshinobu KoguchiWilliam L RedmondBrady BernardVenkatesh RajamanickamNathan PolaskePaul A FieldsValerie ConradMark SchmidtWalter J UrbaAlison K ConlinHeather L McArthurDavid B Page
Published in: Journal for immunotherapy of cancer (2022)
Chemoimmunotherapy for metastatic TNBC with pembrolizumab and capecitabine or paclitaxel resulted in similar peripheral T-cell subset lymphodepletion without altering T-cell clonal diversity. Regression modeling methods are applicable in immune monitoring studies, such as this to identify the odds of novel T-cell clones emerging during treatment, and proliferation rates of tumor-enriched T-cell clones.
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