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Pcpe2, a Novel Extracellular Matrix Protein, Regulates Adipocyte SR-BI-Mediated High-Density Lipoprotein Uptake.

Hao XuMichael J ThomasSushma KaulRachel KallingerAmber B OuweneelElisa MarukoSabrina M OussaadaAldo JongejanHuib A CenseMax NieuwdorpMireille J SerlieIra J GoldbergMete CivelekBrian W ParksAldons J LusisDarcy KnaackRebecca L SchillSarah C MayJohn J RehoJustin L GrobeBenjamin GantnerDaisy SahooMary G Sorci-Thomas
Published in: Arteriosclerosis, thrombosis, and vascular biology (2021)
Overall, these findings reveal a novel and unexpected function for Pcpe2 in modulating SR-BI expression and function as it relates to adipose tissue expansion and cholesterol balance in both mice and humans.
Keyphrases
  • extracellular matrix
  • adipose tissue
  • high density
  • insulin resistance
  • poor prognosis
  • low density lipoprotein
  • binding protein
  • high fat diet
  • signaling pathway
  • single cell
  • metabolic syndrome
  • genome wide
  • small molecule