Increased colonic propionate reduces anticipatory reward responses in the human striatum to high-energy foods.
Claire S ByrneEdward S ChambersHabeeb AlhabeebNavpreet ChhinaDouglas J MorrisonTom PrestonCatriona TedfordJulie FitzpatrickCherag IraniAlbert BuszaIsabel Garcia-PerezSofia FountanaElaine HolmesAnthony P GoldstoneGary S FrostPublished in: The American journal of clinical nutrition (2016)
Our results suggest that colonic propionate production may play an important role in attenuating reward-based eating behavior via striatal pathways, independent of changes in plasma PYY and GLP-1. This trial was registered at clinicaltrials.gov as NCT00750438.