Effectiveness of pharmacological interventions for managing ADHD symptoms in individuals with autism spectrum disorder: A systematic review and meta-analysis.

Paulo Levi Bezerra MartinsGustavo César Parente TorquatoGabriel Alberto Pinheiro Fernandes DiasIsabel Bessa LeiteThays Macedo GasparJoel Porfírio PintoDanielle S Macedo

Published in: Progress in neuro-psychopharmacology & biological psychiatry (2024)

Our results indicated that atomoxetine has a modest effect on hyperactivity and inattention symptoms, with a relatively benign profile of side effects. MPH appears to be effective in handling hyperactivity, inattention, and irritability symptoms. However, our results on atomoxetine revealed increased dropouts due to adverse effects when compared to MPH or placebo. Evidence for other substances such as guanfacine, clonidine, bupropion, or modafinil is either preliminary or nonexistent.

Keyphrases

attention deficit hyperactivity disorder
sleep quality
randomized controlled trial
physical activity
working memory
clinical trial
depressive symptoms
double blind