Anti-Hu Antibodies in Patients With Neurologic Side Effects of Immune Checkpoint Inhibitors.
Antonio FarinaMacarena Villagrán-GarcíaNicolás Lundahl Ciano-PetersenAlberto VogrigSergio Muñiz-CastrilloLuc TaillandierMaud MichaudMathilde LefilliatreAdrien WangZoe LepineGéraldine PicardValentin WucherMaroua DhairiNicole FabienDavid GoncalvesVéronique RogemondBastien JoubertJèrôme HonnoratPublished in: Neurology(R) neuroimmunology & neuroinflammation (2022)
The presence of Hu-Ab identifies a subgroup of n-irAEs that consistently reproduce the phenotypes of Hu-Ab-related PNS, supporting the hypothesis of ICI triggering or unmasking PNS. As these patients show high disability and mortality, further studies are required to investigate the underlying immunopathogenic mechanisms and to improve the outcome of Hu-Ab n-irAEs.