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Associations of LRP5 and MTHFR Gene Variants with Osteoarthritis Prevalence in Elderly Women: A Japanese Cohort Survey Randomly Sampled from a Basic Resident Registry.

Masaki NakanoHaruka YuiShingo KikugawaRyosuke TokidaNoriko SakaiNaoki KondoNaoto EndoHirotaka HaroHiroki ShimodairaTakako SuzukiHiroyuki KatoJun TakahashiYukio Nakamura
Published in: Therapeutics and clinical risk management (2021)
In sum, the present study demonstrated significant associations of LRP5 rs3736228 and MTHFR rs1801133 with knee/hip OA and osteoporosis prevalences and knee OA prevalence, respectively, in Japanese elderly women. These results will help further the understanding of OA pathogenesis and related genetic risk factors.
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