Associations of LRP5 and MTHFR Gene Variants with Osteoarthritis Prevalence in Elderly Women: A Japanese Cohort Survey Randomly Sampled from a Basic Resident Registry.
Masaki NakanoHaruka YuiShingo KikugawaRyosuke TokidaNoriko SakaiNaoki KondoNaoto EndoHirotaka HaroHiroki ShimodairaTakako SuzukiHiroyuki KatoJun TakahashiYukio NakamuraPublished in: Therapeutics and clinical risk management (2021)
In sum, the present study demonstrated significant associations of LRP5 rs3736228 and MTHFR rs1801133 with knee/hip OA and osteoporosis prevalences and knee OA prevalence, respectively, in Japanese elderly women. These results will help further the understanding of OA pathogenesis and related genetic risk factors.
Keyphrases
- knee osteoarthritis
- risk factors
- copy number
- polycystic ovary syndrome
- total knee arthroplasty
- genome wide
- middle aged
- pregnancy outcomes
- community dwelling
- postmenopausal women
- cervical cancer screening
- cross sectional
- rheumatoid arthritis
- breast cancer risk
- bone mineral density
- patient safety
- anterior cruciate ligament
- gene expression
- quality improvement
- insulin resistance
- type diabetes
- metabolic syndrome