Periplaneta americana extract ameliorates dextran sulfate sodium-induced ulcerative colitis via immunoregulatory and PI3K/AKT/NF-κB signaling pathways.
Lianli NiQian LuMiao TangLu TaoHairong ZhaoChenggui ZhangYun YuXiumei WuHeng LiuRi CuiPublished in: Inflammopharmacology (2022)
Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) with a low cure rate. Periplaneta americana is a traditional American Cockroach and reportedly has potential therapeutic roles for UC treatment; however, its mechanisms remain unclear. To address this, we investigated the therapeutic effects and underlying molecular mechanisms of Ento-A, a Periplaneta americana extract, in a dextran sulfate sodium (DSS)-induced chronic and recurrent UC mouse model. Ento-A treatment decreased pro-inflammatory cytokine secretion, disease activity index (DAI), colon mucosa damage index (CMDI), histopathological scores (HS), and increased colon length. Additionally, Ento-A effectively increased interleukin-4 (IL-4), and forkhead transcription factor protein 3 (Foxp3) expression levels, while it abated interferon-γ (IFN-γ) and IL-17 levels in spleen lymphocytes. Conversely, in mesenteric lymph nodes, IL-4 and Foxp3 expression were decreased, while IFN-γ and IL-17 expression was increased. Furthermore, Ento-A blocked p-PI3K, p-AKT,*and p-NF-κB activation. In conclusion, Ento-A improved UC symptoms and exerted therapeutic effects by regulating immune responses and inhibiting PI3K/AKT/NF-κB signaling.
Keyphrases
- pi k akt
- signaling pathway
- ulcerative colitis
- immune response
- poor prognosis
- cell proliferation
- cell cycle arrest
- transcription factor
- disease activity
- mouse model
- induced apoptosis
- dendritic cells
- oxidative stress
- lymph node
- epithelial mesenchymal transition
- regulatory t cells
- systemic lupus erythematosus
- rheumatoid arthritis
- binding protein
- diabetic rats
- ankylosing spondylitis
- drug induced
- high glucose
- long non coding rna
- high resolution
- lps induced
- depressive symptoms
- rectal cancer
- early stage
- anti inflammatory
- atomic force microscopy
- cell death
- juvenile idiopathic arthritis
- dna binding
- physical activity
- endoplasmic reticulum stress
- mass spectrometry