Login / Signup

The FADS1 genotypes modify the effect of linoleic acid-enriched diet on adipose tissue inflammation via pro-inflammatory eicosanoid metabolism.

Maija VaittinenMaria A LankinenPirjo KäkeläJyrki ÅgrenCraig E WheelockMarkku LaaksoUrsula SchwabJussi Pihlajamäki
Published in: European journal of nutrition (2022)
LA-enriched diet increases inflammatory AT gene expression in subjects with the TT genotype, while CC genotype could play a protective role against LA-induced AT inflammation. Overall, the FADS1 variant could modify the dietary LA-induced effects on AT inflammation through the differential biosynthesis of AA-derived eicosanoids.
Keyphrases
  • oxidative stress
  • diabetic rats
  • gene expression
  • adipose tissue
  • high glucose
  • physical activity
  • weight loss
  • fatty acid
  • dna methylation
  • drug induced
  • insulin resistance
  • type diabetes
  • endothelial cells
  • skeletal muscle