The effect of NLRP inflammasome on the regulation of AGEs-induced inflammatory response in human periodontal ligament cells.

Xiaowei YiLan ZhangWanlu LuXuelian TanJunli YuePuyu WangWeizhe XuLing YeDing-Ming Huang

Published in: Journal of periodontal research (2019)

Advanced glycation end products induced inflammatory response in HPDLCs via NLRP1-inflammasome and NLRP3-inflammasome activation in which NF-κB signal pathway was involved. Besides, AGEs promoted the inflammatory response of MDP via NOD2, NLRP1-inflammasome, and NLRP3-inflammasome.

Keyphrases

nlrp inflammasome
inflammatory response
lps induced
lipopolysaccharide induced
high glucose
toll like receptor
endothelial cells
diabetic rats
induced apoptosis
signaling pathway
nuclear factor
cell death
endoplasmic reticulum stress
pluripotent stem cells