Decreased CSF clearance and increased brain amyloid in Alzheimer's disease.

Yi LiHenry RusinekTracy ButlerLidia GlodzikElizabeth PirragliaJohn BabichP David MozleySadek NehmehSilky PahlajaniXiuyuan WangEmily B TanziLiangdong ZhouSara StraussRoxana O CarareNeil TheiseNobuyuki OkamuraMony J de Leon

Published in: Fluids and barriers of the CNS (2022)

Overall, the findings support the hypothesis that failed CSF clearance is a feature of AD that is related to Aβ deposition and to the pathology of AD. Longitudinal studies are needed to determine whether failed CSF clearance is a predictor of progressive amyloidosis or its consequence.

Keyphrases

multiple sclerosis
machine learning
white matter
cognitive decline
cross sectional
deep learning
neural network